About: Manganese(II) Complexes as Potential Contrast Agents for MRI

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Mn2+ has five unpaired d electrons, a long electronic relaxation time, and labile water exchange, which make it an attractive alternative to Gd3+ in the design of contrast agents for medical Magnetic Resonance Imaging. In order to ensure in vivo safety and high contrast agent efficiency, the Mn2+ ion has to be chelated by a ligand that provides high thermodynamic stability and kinetic inertness of the complex and has to have at least one free coordination site for a water molecule. Unfortunately, these two requirements are contradictory, as lower denticity of the ligands, which leads to more inner-sphere water molecules often implies a decreased stability of the complex, and, therefore, it is necessary to find a balance between both requirements. In the last decade, a large amount of experimental data has been collected to characterize the physico-chemical properties of Mn2+ chelates with variable ligand structures. They now allow for establishing trends of how the ligand structure, the rigidity of the ligand scaffold, and its donoracceptor properties influence the thermodynamic, kinetic, and redox stability of the Mn2+ complex. This microreview surveys the current literature in this field. Mn2+ has five unpaired d electrons, a long electronic relaxation time, and labile water exchange, which make it an attractive alternative to Gd3+ in the design of contrast agents for medical Magnetic Resonance Imaging. In order to ensure in vivo safety and high contrast agent efficiency, the Mn2+ ion has to be chelated by a ligand that provides high thermodynamic stability and kinetic inertness of the complex and has to have at least one free coordination site for a water molecule. Unfortunately, these two requirements are contradictory, as lower denticity of the ligands, which leads to more inner-sphere water molecules often implies a decreased stability of the complex, and, therefore, it is necessary to find a balance between both requirements. In the last decade, a large amount of experimental data has been collected to characterize the physico-chemical properties of Mn2+ chelates with variable ligand structures. They now allow for establishing trends of how the ligand structure, the rigidity of the ligand scaffold, and its donoracceptor properties influence the thermodynamic, kinetic, and redox stability of the Mn2+ complex. This microreview surveys the current literature in this field. (en)
Title	Manganese(II) Complexes as Potential Contrast Agents for MRI Manganese(II) Complexes as Potential Contrast Agents for MRI (en)
skos:prefLabel	Manganese(II) Complexes as Potential Contrast Agents for MRI Manganese(II) Complexes as Potential Contrast Agents for MRI (en)
skos:notation	RIV/61989592:15310/12:33142752!RIV13-MSM-15310___
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0058), P(EE2.3.20.0017), S, Z(MSM0021620857)
http://linked.open...iv/cisloPeriodika	SI
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Drahoš, Bohuslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	148032
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/12:33142752
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Kinetics; Thermodynamics; Relaxi-vity; Imaging agents; Magnetic Resonance Imaging; Manganese (en)
http://linked.open.../riv/klicoveSlovo	Magnetic Resonance Imaging Thermodynamics Imaging agents Manganese Relaxi-vity Kinetics
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[74987CB22069]
http://linked.open...i/riv/nazevZdroje	European Journal of Inorganic Chemistry
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Regional Centre of Advanced Technologies and Materials Research team development of the Regional Centre of Advanced Technologies and Materials
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Lukeš, Ivan Drahoš, Bohuslav Toth, Eva
http://linked.open...ain/vavai/riv/wos	000302861900009
http://linked.open...n/vavai/riv/zamer	Nové molekulární systémy pro pokročilé aplikace prospěšné pro zdraví a šetrné k životnímu prostředí
issn	1434-1948
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ejic.201101336
http://localhost/t...ganizacniJednotka	15310

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