About: A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.nature.com/nature/journal/v485/n7396/full/nature11001.html
Description	The phytohormone auxin acts as a prominent signal, providing, by its local accumulation or depletion in selected cells, a spatial and temporal reference for changes in the developmental program(1-7). The distribution of auxin depends on both auxin metabolism (biosynthesis, conjugation and degradation)(8-10) and cellular auxin transport(11-15). We identified in silico a novel putative auxin transport facilitator family, called PIN-LIKES (PILS). Here we illustrate that PILS proteins are required for auxin-dependent regulation of plant growth by determining the cellular sensitivity to auxin. PILS proteins regulate intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signalling. PILS activity affects the level of endogenous auxin indole-3-acetic acid (IAA), presumably via intracellular accumulation and metabolism. Our findings reveal that the transport machinery to compartmentalize auxin within the cell is of an unexpected molecular complexity and demonstrate this compartmentalization to be functionally important for a number of developmental processes. The phytohormone auxin acts as a prominent signal, providing, by its local accumulation or depletion in selected cells, a spatial and temporal reference for changes in the developmental program(1-7). The distribution of auxin depends on both auxin metabolism (biosynthesis, conjugation and degradation)(8-10) and cellular auxin transport(11-15). We identified in silico a novel putative auxin transport facilitator family, called PIN-LIKES (PILS). Here we illustrate that PILS proteins are required for auxin-dependent regulation of plant growth by determining the cellular sensitivity to auxin. PILS proteins regulate intracellular auxin accumulation at the endoplasmic reticulum and thus auxin availability for nuclear auxin signalling. PILS activity affects the level of endogenous auxin indole-3-acetic acid (IAA), presumably via intracellular accumulation and metabolism. Our findings reveal that the transport machinery to compartmentalize auxin within the cell is of an unexpected molecular complexity and demonstrate this compartmentalization to be functionally important for a number of developmental processes. (en)
Title	A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants (en)
skos:prefLabel	A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants (en)
skos:notation	RIV/61989592:15310/12:33142715!RIV13-AV0-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP305/11/0797), P(GAP305/11/2476), P(KAN200380801), P(LC06034), Z(AV0Z50380511)
http://linked.open...iv/cisloPeriodika	7396
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Dobrev, Petre Rolčík, Jakub Friml, Jiří Pěnčík, Aleš Kleine-Vehn, Jürgen
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	120480
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/12:33142715
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	purification; localization; biosynthesis; proteins; transport; efflux; arabidopsis; abscisic-acid; tobacco cells; solid-phase extraction (en)
http://linked.open.../riv/klicoveSlovo	arabidopsis abscisic-acid efflux tobacco cells solid-phase extraction localization proteins transport biosynthesis purification
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[1EBA792B7A45]
http://linked.open...i/riv/nazevZdroje	Nature
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	15 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunonanotechnologies for hormone diagnostic Molecular mechanisms controlling homeostasis of plant growth regulatory compound auxin Transport auxinu a cytoskelet v morfogenezi rostlinných buněk. Regulation of morphogenesis of plant cells and organs
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	485
http://linked.open...iv/tvurceVysledku	Friml, Jiří Petrášek, Jan Rolčík, Jakub Zažímalová, Eva Barbez, Elke Beziat, Chloe Dobrev, Petre Ivanov Geisler, Markus Kleine-Vehn, Jürgen Kubeš, Martin Lee, Yuree Pěnčík, Aleš Rosquete, Michel Ruiz Wang, Bangjun Zhu, Jinsheng
http://linked.open...ain/vavai/riv/wos	000303451900046
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy
issn	0028-0836
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/nature11001
http://localhost/t...ganizacniJednotka	15310

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