About: Platinum-DNA interstrand crosslinks: Molecular determinants of bending and unwinding of the double helix

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Platinum-DNA interstrand crosslinks: Molecular determinants of bending and unwinding of the double helix Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Platinum diamine complexes are able to crosslink the guanines of d(GC)2 dinucleotides within double-stranded DNA. The interstrand crosslink thus formed causes a bend of the double helix toward the minor groove and the helical sense changes locally to left-handed, resulting in a considerable unwinding. We have used molecular dynamics simulations to investigate the DNA 20-mer containing interstrand cross-link of cis-Pt(NH3)22+, Pt(R,R-DACH)2+, or Pt(S,S-DACH)2+. Molecular determinants of bending and unwinding of the DNA double helix have been determined. Platinum diamine complexes are able to crosslink the guanines of d(GC)2 dinucleotides within double-stranded DNA. The interstrand crosslink thus formed causes a bend of the double helix toward the minor groove and the helical sense changes locally to left-handed, resulting in a considerable unwinding. We have used molecular dynamics simulations to investigate the DNA 20-mer containing interstrand cross-link of cis-Pt(NH3)22+, Pt(R,R-DACH)2+, or Pt(S,S-DACH)2+. Molecular determinants of bending and unwinding of the DNA double helix have been determined. (en)
Title	Platinum-DNA interstrand crosslinks: Molecular determinants of bending and unwinding of the double helix Platinum-DNA interstrand crosslinks: Molecular determinants of bending and unwinding of the double helix (en)
skos:prefLabel	Platinum-DNA interstrand crosslinks: Molecular determinants of bending and unwinding of the double helix Platinum-DNA interstrand crosslinks: Molecular determinants of bending and unwinding of the double helix (en)
skos:notation	RIV/61989592:15310/12:33142325!RIV13-MSM-15310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GD301/09/H004), P(GP202/08/P416), P(OC09018), S, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	MAR
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Brabec, Viktor Kašpárková, Jana Suchánková, Tereza
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	158899
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/12:33142325
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	platinum, interstrand cross-link, molecular dynamics simulations (en)
http://linked.open.../riv/klicoveSlovo	molecular dynamics simulations platinum interstrand cross-link
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BD3563C9F8EB]
http://linked.open...i/riv/nazevZdroje	Journal of Inorganic Biochemistry
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors Mechanism of antitumor activity of metallodrugs. DNA replication and repair of DNA damage NMR study of interaction of cisplatined G/T mismatched DNA substrate with protein MutS
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Brabec, Viktor Kašpárková, Jana Kozelka, Jiří Kubíček, Karel Suchánková, Tereza
http://linked.open...ain/vavai/riv/wos	000302205600010
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0162-0134
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.jinorgbio.2011.09.025
http://localhost/t...ganizacniJednotka	15310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software