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rdf:type
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Description
| - The results demonstrate for the first time that little conformational distortions induced by new antitumor azolato-bridged dinuclear PtII complexes, such as [{cis-Pt(NH3)2}2(?-OH)(?-pyrazolate)]2+ in highly polymeric DNA with a random nucleotide sequence represent a structural motif recognizable by DNA repair systems less efficiently than distortions induced by cisplatin. Thus, DNA adducts of azolato-bridged dinuclear PtII complexes can escape repair mechanisms more easily than those of cisplatin, which may potentiate antitumor effects of these new metallodrugs in cancer cells.
- The results demonstrate for the first time that little conformational distortions induced by new antitumor azolato-bridged dinuclear PtII complexes, such as [{cis-Pt(NH3)2}2(?-OH)(?-pyrazolate)]2+ in highly polymeric DNA with a random nucleotide sequence represent a structural motif recognizable by DNA repair systems less efficiently than distortions induced by cisplatin. Thus, DNA adducts of azolato-bridged dinuclear PtII complexes can escape repair mechanisms more easily than those of cisplatin, which may potentiate antitumor effects of these new metallodrugs in cancer cells. (en)
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Title
| - DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear PtII complex
- DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear PtII complex (en)
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skos:prefLabel
| - DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear PtII complex
- DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear PtII complex (en)
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skos:notation
| - RIV/61989592:15310/12:33142301!RIV13-MSM-15310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GAP301/10/0598), P(GD301/09/H004), S, Z(AV0Z50040702)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/12:33142301
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - DNA, platinum, DNA repair (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of Inorganic Biochemistry
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Brabec, Viktor
- Kašpárková, Jana
- Suchánková, Tereza
- Mlčoušková, Jarmila
- Komeda, Seiji
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.jinorgbio.2012.04.015
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http://localhost/t...ganizacniJednotka
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