About: Practical Aspects of Combinatorial Solid-Phase Synthesis

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Combinatorial chemistry is a powerful and efficient technology that has already become an integral part of discovery processes, including drug discovery. In contrast to the traditional medicinal chemistry approach characterized by evaluating the effect of one structural modification at a time, the fundamental aspect of the combinatorial approach resides in the opportunity to evaluate the effect of a combination of individual structural and functional modifications in a molecule. As a result of the combinatorial method of constructing compounds, the number of synthesized compounds exceeds the traditional approach by several orders of magnitude and provides chemical libraries. Hence, the logistics and instrumentation for combinatorial synthesis are an important issue. In this contribution, we will discuss the logistics and practical aspects of combinatorial solid-phase synthesis. Combinatorial chemistry is a powerful and efficient technology that has already become an integral part of discovery processes, including drug discovery. In contrast to the traditional medicinal chemistry approach characterized by evaluating the effect of one structural modification at a time, the fundamental aspect of the combinatorial approach resides in the opportunity to evaluate the effect of a combination of individual structural and functional modifications in a molecule. As a result of the combinatorial method of constructing compounds, the number of synthesized compounds exceeds the traditional approach by several orders of magnitude and provides chemical libraries. Hence, the logistics and instrumentation for combinatorial synthesis are an important issue. In this contribution, we will discuss the logistics and practical aspects of combinatorial solid-phase synthesis. (en)
Title	Practical Aspects of Combinatorial Solid-Phase Synthesis Practical Aspects of Combinatorial Solid-Phase Synthesis (en)
skos:prefLabel	Practical Aspects of Combinatorial Solid-Phase Synthesis Practical Aspects of Combinatorial Solid-Phase Synthesis (en)
skos:notation	RIV/61989592:15310/12:33141482!RIV13-MSM-15310___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED0030/01/01)
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Soural, Miroslav Hlaváč, Jan Krchňák, Viktor
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	160692
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/12:33141482
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Applications; Strategies; Concepts; Synthesis; Organic; Solid-Phase; Combinatorial; Aspects; Practical (en)
http://linked.open.../riv/klicoveSlovo	Concepts Aspects Synthesis Practical Applications Combinatorial Organic Strategies Solid-Phase
http://linked.open...ontrolniKodProRIV	[7008CCB54F80]
http://linked.open...i/riv/mistoVydani	New Jersey
http://linked.open...i/riv/nazevZdroje	Solid-Phase Organic Synthesis: Concepts, Strategies and Applications
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...v/pocetStranKnihy	536 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedicine for regional development and human resources
http://linked.open...UplatneniVysledku	2012
http://linked.open...iv/tvurceVysledku	Hlaváč, Jan Soural, Miroslav Krchňák, Viktor
number of pages	36 (xsd:int)
http://purl.org/ne...btex#hasPublisher	John Wiley
https://schema.org/isbn	978-0-470-59914-3
http://localhost/t...ganizacniJednotka	15310

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