About: CONTROLLED BAND DISPERSION FOR QUANTITATIVE BINDING DETERMINATION AND ANALYSIS WITH ELECTROSPRAY IONIZATION-MASS SPECTROMETRY

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This review discusses recent emerging techniques that have been used to couple flow-injection analysis (FIA) and electrospray ionization-mass spectrometry (ESI-MS) for the quantitation of noncovalent binding interactions. Focus is placed predominantly on two such methods. Diffusion-based measurements, developed by Konermann and co-workers, uses controlled-band dispersion prior to ESI-MS to determine diffusion constants and binding constants based on the temporal variation of ligand signal measured in the mass spectrum (an indirect technique). Dynamic titration, developed by Schug and co-workers, is a direct method, where a temporal compositional gradient of a guest molecule is induced in the presence of host in solution to monitor the concentration dependence of complex formation as a function of observed complex ion abundance after ESI-MS. Further discussion places these techniques in the context of a variety of other direct and indirect ESI-MS-based binding determination methods. This review discusses recent emerging techniques that have been used to couple flow-injection analysis (FIA) and electrospray ionization-mass spectrometry (ESI-MS) for the quantitation of noncovalent binding interactions. Focus is placed predominantly on two such methods. Diffusion-based measurements, developed by Konermann and co-workers, uses controlled-band dispersion prior to ESI-MS to determine diffusion constants and binding constants based on the temporal variation of ligand signal measured in the mass spectrum (an indirect technique). Dynamic titration, developed by Schug and co-workers, is a direct method, where a temporal compositional gradient of a guest molecule is induced in the presence of host in solution to monitor the concentration dependence of complex formation as a function of observed complex ion abundance after ESI-MS. Further discussion places these techniques in the context of a variety of other direct and indirect ESI-MS-based binding determination methods. (en)
Title	CONTROLLED BAND DISPERSION FOR QUANTITATIVE BINDING DETERMINATION AND ANALYSIS WITH ELECTROSPRAY IONIZATION-MASS SPECTROMETRY CONTROLLED BAND DISPERSION FOR QUANTITATIVE BINDING DETERMINATION AND ANALYSIS WITH ELECTROSPRAY IONIZATION-MASS SPECTROMETRY (en)
skos:prefLabel	CONTROLLED BAND DISPERSION FOR QUANTITATIVE BINDING DETERMINATION AND ANALYSIS WITH ELECTROSPRAY IONIZATION-MASS SPECTROMETRY CONTROLLED BAND DISPERSION FOR QUANTITATIVE BINDING DETERMINATION AND ANALYSIS WITH ELECTROSPRAY IONIZATION-MASS SPECTROMETRY (en)
skos:notation	RIV/61989592:15310/10:10215676!RIV11-MSM-15310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Fryčák, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	252085
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/10:10215676
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	affinity mass spectrometry; diffusion; flow-injection analysis; noncovalent interactions; dynamic titration (en)
http://linked.open.../riv/klicoveSlovo	noncovalent interactions diffusion affinity mass spectrometry dynamic titration flow-injection analysis
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8C92F3053E94]
http://linked.open...i/riv/nazevZdroje	Mass Spectrometry Reviews
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Fryčák, Petr Schug, Kevin Serrano, Carlos
http://linked.open...ain/vavai/riv/wos	000281724300006
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0277-7037
number of pages	24 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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