About: The roles of p27Kip1 and DNA damage signalling in the chemotherapy-induced delayed cell cycle checkpoint     Goto   Sponge   NotDistinct   Permalink

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Description
  • DNA lesions trigger the DNA damage response (DDR) machinery, which protects genomic integrity and sustains cellular survival. Increasing data underline the significance of the integrity of the DDR pathway in chemotherapy response. According to a recent work, persistent exposure of A549 lung carcinoma cells to doxorubicin induces an initial DDR-dependent checkpoint response, followed by a later DDR-independent, but p27Kip1-dependent one.
  • DNA lesions trigger the DNA damage response (DDR) machinery, which protects genomic integrity and sustains cellular survival. Increasing data underline the significance of the integrity of the DDR pathway in chemotherapy response. According to a recent work, persistent exposure of A549 lung carcinoma cells to doxorubicin induces an initial DDR-dependent checkpoint response, followed by a later DDR-independent, but p27Kip1-dependent one. (en)
Title
  • The roles of p27Kip1 and DNA damage signalling in the chemotherapy-induced delayed cell cycle checkpoint
  • The roles of p27Kip1 and DNA damage signalling in the chemotherapy-induced delayed cell cycle checkpoint (en)
skos:prefLabel
  • The roles of p27Kip1 and DNA damage signalling in the chemotherapy-induced delayed cell cycle checkpoint
  • The roles of p27Kip1 and DNA damage signalling in the chemotherapy-induced delayed cell cycle checkpoint (en)
skos:notation
  • RIV/61989592:15310/10:10215636!RIV11-MSM-15310___
http://linked.open...avai/riv/aktivita
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  • Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 9
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  • 285814
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/10:10215636
http://linked.open...riv/jazykVysledku
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  • SKP2; p38-MAPK; p27Kip1; DNA-PKcs; ATR; ATM; chemotherapy; cell cycle arrest; DNA damage response (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • RO - Rumunsko
http://linked.open...ontrolniKodProRIV
  • [828AD2BB6282]
http://linked.open...i/riv/nazevZdroje
  • Journal of Cellular and Molecular Medicine
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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  • 14
http://linked.open...iv/tvurceVysledku
  • Bártek, Jiří
  • Liontos, Michalis
  • Angelopoulou, Roxani
  • Gorgoulis, Vassilis
  • Papavassiliou, Athanasios
  • Pateras, Ioannis
  • Velimezi, Georgia
http://linked.open...n/vavai/riv/zamer
issn
  • 1582-1838
number of pages
http://localhost/t...ganizacniJednotka
  • 15310
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