About: Palladium(II) oxalato complexes involving N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis, general properties, H-1, C-13 and N-15{H-1} NMR characterization and in vitro cytotoxicity

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About: Palladium(II) oxalato complexes involving N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis, general properties, H-1, C-13 and N-15{H-1} NMR characterization and in vitro cytotoxicity Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A series of seven palladium(II) oxalato (ox) complexes of the general formula [Pd(ox)(L1-7)(2)].nH(2)O (1-7; n = 0 for 4, 5 and 7, (3)/(4) for 1 and 2, 1 for 6, and 3 for 3) has been prepared. The compounds were characterized by elemental analysis, IR, Raman, H-1, C-13 and N-15{H-1} NMR spectroscopy, ESI+ mass spectrometry, molar conductivity and TG/DTA thermal analysis. The geometry of [Pd(ox)(L-2)(2)] (2) was optimized on the B3LYP/6-311G/LANL2DZ level of theory. The complexes 4-7 represent the first palladium(II) oxalato complexes with a PdN2O2 donor set, which involve highly potent purine-based cyclin-dependent kinase (CDK) inhibitors (L4-7) as carrier N-donor ligands. The selected complexes 1, 3-5 and 7 were tested by an MTT assay for their in vitro cytotoxic activity against human osteosarcoma (HOS) cancer cell line. A series of seven palladium(II) oxalato (ox) complexes of the general formula [Pd(ox)(L1-7)(2)].nH(2)O (1-7; n = 0 for 4, 5 and 7, (3)/(4) for 1 and 2, 1 for 6, and 3 for 3) has been prepared. The compounds were characterized by elemental analysis, IR, Raman, H-1, C-13 and N-15{H-1} NMR spectroscopy, ESI+ mass spectrometry, molar conductivity and TG/DTA thermal analysis. The geometry of [Pd(ox)(L-2)(2)] (2) was optimized on the B3LYP/6-311G/LANL2DZ level of theory. The complexes 4-7 represent the first palladium(II) oxalato complexes with a PdN2O2 donor set, which involve highly potent purine-based cyclin-dependent kinase (CDK) inhibitors (L4-7) as carrier N-donor ligands. The selected complexes 1, 3-5 and 7 were tested by an MTT assay for their in vitro cytotoxic activity against human osteosarcoma (HOS) cancer cell line. (en)
Title	Palladium(II) oxalato complexes involving N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis, general properties, H-1, C-13 and N-15{H-1} NMR characterization and in vitro cytotoxicity Palladium(II) oxalato complexes involving N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis, general properties, H-1, C-13 and N-15{H-1} NMR characterization and in vitro cytotoxicity (en)
skos:prefLabel	Palladium(II) oxalato complexes involving N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis, general properties, H-1, C-13 and N-15{H-1} NMR characterization and in vitro cytotoxicity Palladium(II) oxalato complexes involving N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis, general properties, H-1, C-13 and N-15{H-1} NMR characterization and in vitro cytotoxicity (en)
skos:notation	RIV/61989592:15310/10:10213241!RIV11-MSM-15310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959218)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Trávníček, Zdeněk Popa, Igor Štarha, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	277965
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/10:10213241
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	In vitro cytotoxicity; CDK inhibitors; Adenine derivatives; Oxalate; Palladium(II) complexes (en)
http://linked.open.../riv/klicoveSlovo	In vitro cytotoxicity Adenine derivatives Oxalate CDK inhibitors Palladium(II) complexes
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[B023B3F11AC2]
http://linked.open...i/riv/nazevZdroje	Inorganica Chimica Acta
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	363
http://linked.open...iv/tvurceVysledku	Trávníček, Zdeněk Štarha, Pavel Popa, Igor
http://linked.open...ain/vavai/riv/wos	000276190300021
http://linked.open...n/vavai/riv/zamer	Komplexní sloučeniny a oxidy přechodných kovů s využitím v bioaplikacích a nanotechnologiích
issn	0020-1693
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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