About: Platinum(II) oxalato complexes with adenine-based carrier ligands showing significant in vitro antitumor activity     Goto   Sponge   NotDistinct   Permalink

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Description
  • [Pt(L)(2)(ox)] (1), [Pt(2-OMeL)(2)(ox)] (2), [Pt(3-OMeL)(2)(ox)] (3), [Pt(2,3-diOMeL)(2)(ox)] (4), [Pt(2,4-diOMeL)(2)(ox)] (5), [Pt(3,4-diOMeL)(2)(ox)] (6) and [Pt(3,5-diOMeL)(2)(ox)].4H(2)O (7) platinum(II) oxalato (ox) complexes were synthesized. A single-crystal X-ray analysis of [Pt(2,4-diOMeL)(2)(ox)].2DMF (5.2DMF), proved the slightly distorted square-planar geometry in the vicinity of the Pt(II) ion with one bidentate-coordinated oxalate dianion and two adenine derivatives (nL) coordinated to the Pt(II) centre through the N7 atom of an adenine moiety, thereby giving a PtN2O2 donor set. In vitro cytotoxicity of the prepared complexes was tested by an MTT assay against osteosarcoma (HOS) and breast adenocarcinoma (MCF7) human cancer cell lines.
  • [Pt(L)(2)(ox)] (1), [Pt(2-OMeL)(2)(ox)] (2), [Pt(3-OMeL)(2)(ox)] (3), [Pt(2,3-diOMeL)(2)(ox)] (4), [Pt(2,4-diOMeL)(2)(ox)] (5), [Pt(3,4-diOMeL)(2)(ox)] (6) and [Pt(3,5-diOMeL)(2)(ox)].4H(2)O (7) platinum(II) oxalato (ox) complexes were synthesized. A single-crystal X-ray analysis of [Pt(2,4-diOMeL)(2)(ox)].2DMF (5.2DMF), proved the slightly distorted square-planar geometry in the vicinity of the Pt(II) ion with one bidentate-coordinated oxalate dianion and two adenine derivatives (nL) coordinated to the Pt(II) centre through the N7 atom of an adenine moiety, thereby giving a PtN2O2 donor set. In vitro cytotoxicity of the prepared complexes was tested by an MTT assay against osteosarcoma (HOS) and breast adenocarcinoma (MCF7) human cancer cell lines. (en)
Title
  • Platinum(II) oxalato complexes with adenine-based carrier ligands showing significant in vitro antitumor activity
  • Platinum(II) oxalato complexes with adenine-based carrier ligands showing significant in vitro antitumor activity (en)
skos:prefLabel
  • Platinum(II) oxalato complexes with adenine-based carrier ligands showing significant in vitro antitumor activity
  • Platinum(II) oxalato complexes with adenine-based carrier ligands showing significant in vitro antitumor activity (en)
skos:notation
  • RIV/61989592:15310/10:10213234!RIV11-MSM-15310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM6198959218)
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 279158
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/10:10213234
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • In vitro cytotoxicity; Crystal structures; Adenine derivatives; Oxalate; Platinum(II) complexes (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [556E7C7EE0B7]
http://linked.open...i/riv/nazevZdroje
  • Journal of Inorganic Biochemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 104
http://linked.open...iv/tvurceVysledku
  • Trávníček, Zdeněk
  • Štarha, Pavel
  • Popa, Igor
http://linked.open...ain/vavai/riv/wos
  • 000277946300004
http://linked.open...n/vavai/riv/zamer
issn
  • 0162-0134
number of pages
http://localhost/t...ganizacniJednotka
  • 15310
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