About: In Vitro Cytotoxic-Active Platinum(II) Complexes Derived from Carboplatin and Involving Purine Derivatives

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Six platinum(II) complexes of the general formula [Pt(cbdc)-(HLn)(2)] (1-6; cbdc = cyclobutane-1,1-dicarboxylate and HL1-HL6 = benzyl-substituted 6-benzylamino-2-chloro-9-iso-propylpurine derivatives) have been synthesized. The prepared complexes were characterized by elemental analysis and FTIR, Raman and NMR spectroscopy. The complexes 1-6 were tested for their in vitro cytotoxicity against K-562 (chronic myelogenous leukaemia) and MCF7 (breast adenocarcinoma) human cancer cell lines. Values of IC50 ranged from 4.5 to 14.1 mu m for the K-562 cells and from 4.3 to 21.0 mu m for the MCF7 cells. Six platinum(II) complexes of the general formula [Pt(cbdc)-(HLn)(2)] (1-6; cbdc = cyclobutane-1,1-dicarboxylate and HL1-HL6 = benzyl-substituted 6-benzylamino-2-chloro-9-iso-propylpurine derivatives) have been synthesized. The prepared complexes were characterized by elemental analysis and FTIR, Raman and NMR spectroscopy. The complexes 1-6 were tested for their in vitro cytotoxicity against K-562 (chronic myelogenous leukaemia) and MCF7 (breast adenocarcinoma) human cancer cell lines. Values of IC50 ranged from 4.5 to 14.1 mu m for the K-562 cells and from 4.3 to 21.0 mu m for the MCF7 cells. (en)
Title	In Vitro Cytotoxic-Active Platinum(II) Complexes Derived from Carboplatin and Involving Purine Derivatives In Vitro Cytotoxic-Active Platinum(II) Complexes Derived from Carboplatin and Involving Purine Derivatives (en)
skos:prefLabel	In Vitro Cytotoxic-Active Platinum(II) Complexes Derived from Carboplatin and Involving Purine Derivatives In Vitro Cytotoxic-Active Platinum(II) Complexes Derived from Carboplatin and Involving Purine Derivatives (en)
skos:notation	RIV/61989592:15310/10:10213214!RIV11-MSM-15310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959218)
http://linked.open...iv/cisloPeriodika	22
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Trávníček, Zdeněk Popa, Igor Dvořák, Lukáš Štarha, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	263290
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/10:10213214
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Antitumor agents; Cytotoxicity; Nucleobases; Platinum (en)
http://linked.open.../riv/klicoveSlovo	Antitumor agents Cytotoxicity Nucleobases Platinum
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[FBFBADA3AFF4]
http://linked.open...i/riv/nazevZdroje	EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
http://linked.open...in/vavai/riv/obor	CA
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2010
http://linked.open...iv/tvurceVysledku	Trávníček, Zdeněk Štarha, Pavel Dvořák, Lukáš Popa, Igor
http://linked.open...ain/vavai/riv/wos	000281061700006
http://linked.open...n/vavai/riv/zamer	Komplexní sloučeniny a oxidy přechodných kovů s využitím v bioaplikacích a nanotechnologiích
issn	1434-1948
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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