About: The preparation of magnetically guided lipid based nanoemulsions using self-emulsifying technology

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About: The preparation of magnetically guided lipid based nanoemulsions using self-emulsifying technology Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This paper reports an easy and highly reproducible preparation route, using self-emulsifying technology, for an orally administered high quality magnetically responsive drug delivery system. Hydrophobic iron oxide nanoparticles of about 5 nm in diameter were prepared and incorporated into the lipid core of the produced oil droplets of a self-nanoemulsifying drug delivery system (MagC(18)/SNEDDS). The produced nanoemulsion exhibits colloidal stability at high ionic strengths and temperatures. The observed value of the saturation magnetization at 2 K is approximate to 4.1 emu g(-1). The nanoemulsion displayed the magnetic properties of a non-interacting assembly of superparamagnetic particles and a low blocking temperature. Moreover the effect of MagC(18)/SNEDDS on biological systems in vitro was investigated in rodent fibroblasts (3T3 cells). The cytotoxicity studies show that none of the formulations tested affected cell activity significantly over the 24 h incubation. This paper reports an easy and highly reproducible preparation route, using self-emulsifying technology, for an orally administered high quality magnetically responsive drug delivery system. Hydrophobic iron oxide nanoparticles of about 5 nm in diameter were prepared and incorporated into the lipid core of the produced oil droplets of a self-nanoemulsifying drug delivery system (MagC(18)/SNEDDS). The produced nanoemulsion exhibits colloidal stability at high ionic strengths and temperatures. The observed value of the saturation magnetization at 2 K is approximate to 4.1 emu g(-1). The nanoemulsion displayed the magnetic properties of a non-interacting assembly of superparamagnetic particles and a low blocking temperature. Moreover the effect of MagC(18)/SNEDDS on biological systems in vitro was investigated in rodent fibroblasts (3T3 cells). The cytotoxicity studies show that none of the formulations tested affected cell activity significantly over the 24 h incubation. (en)
Title	The preparation of magnetically guided lipid based nanoemulsions using self-emulsifying technology The preparation of magnetically guided lipid based nanoemulsions using self-emulsifying technology (en)
skos:prefLabel	The preparation of magnetically guided lipid based nanoemulsions using self-emulsifying technology The preparation of magnetically guided lipid based nanoemulsions using self-emulsifying technology (en)
skos:notation	RIV/61989592:15310/10:10212120!RIV11-MSM-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KAN115600801), P(KAN200380801), Z(MSM6198959218)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Zbořil, Radek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	281370
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/10:10212120
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	particles; formulations; oxide nanoparticles; oral delivery; drug-delivery systems (en)
http://linked.open.../riv/klicoveSlovo	oxide nanoparticles particles drug-delivery systems formulations oral delivery
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[F27C47F2E0D0]
http://linked.open...i/riv/nazevZdroje	Nanotechnology
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunonanotechnologies for hormone diagnostic New technologies of preparation and exploitation of iron oxide-based nanoparticles for environmental, industrial and medical applications
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	21
http://linked.open...iv/tvurceVysledku	Zbořil, Radek Bakandritsos, Aristides Bouropoulos, Nikolaos Fatouros, Dimitros G. Favretto, Marco E. Kallinteri, Paraskevi Mullertz, Anette Parker, Terry L.
http://linked.open...ain/vavai/riv/wos	000273348400004
http://linked.open...n/vavai/riv/zamer	Komplexní sloučeniny a oxidy přechodných kovů s využitím v bioaplikacích a nanotechnologiích
issn	0957-4484
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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