About: Activation of MAPKs influences the expression of drug-metabolizing enzymes in primary human hepatocytes

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About: Activation of MAPKs influences the expression of drug-metabolizing enzymes in primary human hepatocytes Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We examined the effects of model activators of mitogen-activated protein kinases (MAPKs) on basal and rifampicin, phenobarbital- and dioxin-inducible expression of phase I and phase II biotransformation enzymes in primary human hepatocytes. Cells were treated for 24 h with sorbitol (SOR), anisomycin (ANI) and epidermal growth factor (EGF) in the presence or absence of inducers. The levels of CYP1A1, CYP1A2, CYP2B6, CYP3A4, UGT1A1, UGT2B17, SULT1A1, SULT2A1, SULT1B2, GSTA1, GSTA2 mRNAs were determined. SOR and EGF inhibited the expression of the tested genes, while ANI had no effect. We conclude that MAPKs play important role in the transcriptional regulation of drug-metabolizing enzymes. We examined the effects of model activators of mitogen-activated protein kinases (MAPKs) on basal and rifampicin, phenobarbital- and dioxin-inducible expression of phase I and phase II biotransformation enzymes in primary human hepatocytes. Cells were treated for 24 h with sorbitol (SOR), anisomycin (ANI) and epidermal growth factor (EGF) in the presence or absence of inducers. The levels of CYP1A1, CYP1A2, CYP2B6, CYP3A4, UGT1A1, UGT2B17, SULT1A1, SULT2A1, SULT1B2, GSTA1, GSTA2 mRNAs were determined. SOR and EGF inhibited the expression of the tested genes, while ANI had no effect. We conclude that MAPKs play important role in the transcriptional regulation of drug-metabolizing enzymes. (en)
Title	Activation of MAPKs influences the expression of drug-metabolizing enzymes in primary human hepatocytes Activation of MAPKs influences the expression of drug-metabolizing enzymes in primary human hepatocytes (en)
skos:prefLabel	Activation of MAPKs influences the expression of drug-metabolizing enzymes in primary human hepatocytes Activation of MAPKs influences the expression of drug-metabolizing enzymes in primary human hepatocytes (en)
skos:notation	RIV/61989592:15310/09:00010916!RIV10-GA0-15310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA303/07/0128), P(GP305/08/P089)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Vrzal, Radim Dvořák, Zdeněk BACHLEDA, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	301836
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/09:00010916
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Xenoreceptors; MAPKs; Human hepatocytes; Cytochrome P450 (en)
http://linked.open.../riv/klicoveSlovo	Human hepatocytes Cytochrome P450 MAPKs Xenoreceptors
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[1D2CFEA038FC]
http://linked.open...i/riv/nazevZdroje	General Physiology and Biophysics
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Study on tissue-specific aspects of transcriptional regulation of selected P-450 enzymes and drug transporters. The role of MAP kinases in cellular signalling of aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	28
http://linked.open...iv/tvurceVysledku	Dvořák, Zdeněk Vrzal, Radim Bachleda, Petr
http://linked.open...ain/vavai/riv/wos	000272335700013
issn	0231-5882
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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