About: 4-arylazo-3,5-diamino-pyrazole compounds and use thereof     Goto   Sponge   NotDistinct   Permalink

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  • A series of mono- and binuclear 4-arylazo-3,5-diamino-pyrazoles which are useful for inhibition of cyclin-dependent kinases (preferably CDK 9). Hence they can be used as antimitotic-, pro-apoptotic and antiinflammatory drugs, in particular, in chemotherapy of cancer and asthma, therapy of psoriasis and parasitoses as those caused by fungi or protits, treatment of Alzheimer´s disease or as antineurodegenerative drugs, or to suppress immunostimulation. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame-retardants, diagnostic reagents and therapeutics, including antivirals and immunosuppressors.
  • A series of mono- and binuclear 4-arylazo-3,5-diamino-pyrazoles which are useful for inhibition of cyclin-dependent kinases (preferably CDK 9). Hence they can be used as antimitotic-, pro-apoptotic and antiinflammatory drugs, in particular, in chemotherapy of cancer and asthma, therapy of psoriasis and parasitoses as those caused by fungi or protits, treatment of Alzheimer´s disease or as antineurodegenerative drugs, or to suppress immunostimulation. These compounds are useful in a variety of utilities, including as intermediates in the preparation of flame-retardants, diagnostic reagents and therapeutics, including antivirals and immunosuppressors. (en)
Title
  • 4-arylazo-3,5-diamino-pyrazole compounds and use thereof
  • 4-arylazo-3,5-diamino-pyrazole compounds and use thereof (en)
skos:prefLabel
  • 4-arylazo-3,5-diamino-pyrazole compounds and use thereof
  • 4-arylazo-3,5-diamino-pyrazole compounds and use thereof (en)
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  • RIV/61989592:15310/09:00010701!RIV10-MSM-15310___
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  • RIV/61989592:15310/09:00010701
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  • 4-arylazo-3; 5-diamino-pyrazole; cyclin-dependent kinase inhibitor; antimitotic drug; antiinflammatory drug; chemotherapy (en)
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  • Kryštof, Vladimír
  • Strnad, Miroslav
  • Cankař, Petr
  • Lenobel, René
  • Fryšová, Iveta
  • Slouka, Jan
  • Fisher, Peter
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  • Univerzita Palackého v Olomouci, Ústav Experimentální Botaniky AV ČR
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  • 15310
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