About: Mass spectrometry as a tool for characterization of N,N-dialkylaminoethane-2-thiols - precursors and degradation products of chemical warfare agents

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	N,N-dialkylaminoethane-2-thiols belong to the group of precursors and degradation products of chemical warfare agents (CWAs). These compounds were analyzed by means of electrospray ionization-multiple stage mass spectrometry (ion trap) and proposed fragments were confirmed by accurate mass measurement using a QqTOF system. The fragmentation pathways of studied compounds and the products of oxidation (formation of -S-S- linkage) were described. Some minor interesting processes, such as rearrangement of SH group, were observed and proved. A new mu LC/MS method, based on ion-pairing chromatography, was developed. Trifluoroacetic acid was employed as an ion-pairing agent to increase the low retention of compounds of interest in the reverse-phase system. The technique was compared with the UPLC/MS method, allowing fast analysis of all the studied thiols as well as an explorative control of originated disulfides. N,N-dialkylaminoethane-2-thiols belong to the group of precursors and degradation products of chemical warfare agents (CWAs). These compounds were analyzed by means of electrospray ionization-multiple stage mass spectrometry (ion trap) and proposed fragments were confirmed by accurate mass measurement using a QqTOF system. The fragmentation pathways of studied compounds and the products of oxidation (formation of -S-S- linkage) were described. Some minor interesting processes, such as rearrangement of SH group, were observed and proved. A new mu LC/MS method, based on ion-pairing chromatography, was developed. Trifluoroacetic acid was employed as an ion-pairing agent to increase the low retention of compounds of interest in the reverse-phase system. The technique was compared with the UPLC/MS method, allowing fast analysis of all the studied thiols as well as an explorative control of originated disulfides. (en)
Title	Mass spectrometry as a tool for characterization of N,N-dialkylaminoethane-2-thiols - precursors and degradation products of chemical warfare agents Mass spectrometry as a tool for characterization of N,N-dialkylaminoethane-2-thiols - precursors and degradation products of chemical warfare agents (en)
skos:prefLabel	Mass spectrometry as a tool for characterization of N,N-dialkylaminoethane-2-thiols - precursors and degradation products of chemical warfare agents Mass spectrometry as a tool for characterization of N,N-dialkylaminoethane-2-thiols - precursors and degradation products of chemical warfare agents (en)
skos:notation	RIV/61989592:15310/09:00010415!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50380511), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hlaváč, Jan Barták, Petr Papoušková, Barbora Lemr, Karel Bednář, Petr Stýskala, Jakub
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	324812
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/09:00010415
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mass spectrometry; chemical warfare agents; N,N-dialkylaminoethane-2-thiols; ion-pairing liquid chromatography; ultra performance liquid chromatography (en)
http://linked.open.../riv/klicoveSlovo	N mass spectrometry chemical warfare agents N-dialkylaminoethane-2-thiols ion-pairing liquid chromatography ultra performance liquid chromatography
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[72A33B487112]
http://linked.open...i/riv/nazevZdroje	Journal of Mass Spectrometry
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	44
http://linked.open...iv/tvurceVysledku	Barták, Petr Bednář, Petr Hlaváč, Jan Lemr, Karel Papoušková, Barbora Stýskala, Jakub
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1076-5174
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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