About: Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant

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About: Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A method for the separation of six selected antihyperglycemic (antidiabetic) drugs (tolbutamide, gliclazide, glimepiride, glibenclamide, repaglinide, and glipizide) was developed with use of micellar electrokinetic chromatography. Two non-ionic poly(ethylene glycol)-based surfactants Genapol X-080 and Triton X-114 (reduced) were studied as neutral pseudostationary phases. High alkaline pH 10.0 was used to obtain negative charges of separated antidiabetic drugs and non-ionic surfactants were employed for selectivity alteration. Both non-ionic surfactants provided good selectivity at concentration 0.2% (v/v) in sodium borate buffer and the separation of six drugs was obtained within 5 min. An on-line preconcentration method based on reversed electrode polarity switching was employed for the determination of anti hyperglycemic drugs in blood serum after acetonitrile protein precipitation. The limits of detection ranged from 20.8 nmol L-(1) for tolbutamide to 6.5 nmol L-1 for glibenclamide, respectively. A method for the separation of six selected antihyperglycemic (antidiabetic) drugs (tolbutamide, gliclazide, glimepiride, glibenclamide, repaglinide, and glipizide) was developed with use of micellar electrokinetic chromatography. Two non-ionic poly(ethylene glycol)-based surfactants Genapol X-080 and Triton X-114 (reduced) were studied as neutral pseudostationary phases. High alkaline pH 10.0 was used to obtain negative charges of separated antidiabetic drugs and non-ionic surfactants were employed for selectivity alteration. Both non-ionic surfactants provided good selectivity at concentration 0.2% (v/v) in sodium borate buffer and the separation of six drugs was obtained within 5 min. An on-line preconcentration method based on reversed electrode polarity switching was employed for the determination of anti hyperglycemic drugs in blood serum after acetonitrile protein precipitation. The limits of detection ranged from 20.8 nmol L-(1) for tolbutamide to 6.5 nmol L-1 for glibenclamide, respectively. (en)
Title	Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant (en)
skos:prefLabel	Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant Determination of antihyperglycemic drugs in nanomolar concentration levels by micellar electrokinetic chromatography with non-ionic surfactant (en)
skos:notation	RIV/61989592:15310/09:00010414!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GP203/07/P223), S, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	20
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Petr, Jan Skopalová, Jana Maier, Vítězslav Ševčík, Juraj Jirovský, David Znaleziona, Joanna
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	309877
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/09:00010414
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Micellar electrokinetic chromatography; Antihyperglycemic drug; Antidiabetic drug; Gliclazide; Glibenclamide; Glimepiride; Glipizide; Repaglinide; Tolbutamide; Non-ionic surfactant; Genapol X-080; Triton X-114 (reduced); On-line preconcentration (en)
http://linked.open.../riv/klicoveSlovo	Antidiabetic drug Tolbutamide Repaglinide Antihyperglycemic drug Genapol X-080 Glibenclamide Gliclazide Glipizide Non-ionic surfactant Triton X-114 (reduced) On-line preconcentration Micellar electrokinetic chromatography Glimepiride
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[53306B245F9B]
http://linked.open...i/riv/nazevZdroje	Journal of Chromatography A: Symposium Volumes
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of discontinuous electrolyte sysmtems in capillary electrophoresis for separation of physiologically active compounds
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	1216
http://linked.open...iv/tvurceVysledku	Petr, Jan Skopalová, Jana Maier, Vítězslav Znaleziona, Joanna Ševčík, Juraj Jirovský, David
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0021-9673
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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