About: Nanoelectrospray versus electrospray in chiral analysis by the kinetic method

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Electrospray ionization generates trimeric diastereoisomeric clusters as the first important step in chiral analysis by mass spectrometry using the Cooks' kinetic method. Cu2+ and L-tryptophan were used as a central metal and as a chiral reference ligand, respectively. The comparison of electrospray and nanoelectrospray showed that although the electrospray system was generally more robust, the application of nanoelectrospray was essential for performing successful analysis in some cases, especially for real samples. Basically, no significant differences between the ion sources were observed for model samples of analytes (isoleucine, ephedrine, phenylalanine) without interfering matrix. On the other hand, model samples containing sodium chloride and a buffer containing a real sample (drug formulation Mucoseptonex E in which D-ephedrine is the active substance) could not be analyzed using ESI, whereas nano-ESI gave satisfactory results. An explanation is based on the differences of ionization proc Electrospray ionization generates trimeric diastereoisomeric clusters as the first important step in chiral analysis by mass spectrometry using the Cooks' kinetic method. Cu2+ and L-tryptophan were used as a central metal and as a chiral reference ligand, respectively. The comparison of electrospray and nanoelectrospray showed that although the electrospray system was generally more robust, the application of nanoelectrospray was essential for performing successful analysis in some cases, especially for real samples. Basically, no significant differences between the ion sources were observed for model samples of analytes (isoleucine, ephedrine, phenylalanine) without interfering matrix. On the other hand, model samples containing sodium chloride and a buffer containing a real sample (drug formulation Mucoseptonex E in which D-ephedrine is the active substance) could not be analyzed using ESI, whereas nano-ESI gave satisfactory results. An explanation is based on the differences of ionization proc (en)
Title	Nanoelectrospray versus electrospray in chiral analysis by the kinetic method Nanoelectrospray versus electrospray in chiral analysis by the kinetic method (en)
skos:prefLabel	Nanoelectrospray versus electrospray in chiral analysis by the kinetic method Nanoelectrospray versus electrospray in chiral analysis by the kinetic method (en)
skos:notation	RIV/61989592:15310/09:00010408!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/07/0765), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Lemr, Karel Bednář, Petr Havlíček, Vladimír Ranc, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	328409
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/09:00010408
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Chiral analysis; Kinetic method; Mass spectrometry; Electrospray; Nanoelectrospray; Amino acids; Drugs; Diastereoisomeric clusters; Gas-phase (en)
http://linked.open.../riv/klicoveSlovo	Gas-phase Drugs Amino acids Mass spectrometry Electrospray Chiral analysis Diastereoisomeric clusters Kinetic method Nanoelectrospray
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[53945EA876FB]
http://linked.open...i/riv/nazevZdroje	Collection of Czechoslovak Chemical Communications
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of isomers by mass spectrometry and kinetic method
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	74
http://linked.open...iv/tvurceVysledku	Bednář, Petr Lemr, Karel Havlíček, Vladimír Ranc, Václav
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0010-0765
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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