About: Nitrace proteinů reaktivními formami dusíku     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • This review summarizes the current knowledge of nitration of tyrosine residues in proteins. Tyrosine residues are nitrated to 3-nitrotyrosine residues by reactive compounds like nitric oxide, nitric dioxide, peroxynitrite and nitrite metabolites as well as by other reactive nitrogen and oxygen species. Peroxynitrites are probably the most important nitration agents in vivo, though other nitrations have also been described. The introduced nitro group influences pKa of the tyrosine residue and its accessibility to phosphorylation as well as protein structure, stability and biological activity. The enhanced nitration of proteins is a consequence of a higher production of reactive nitrogen and oxygen species and/or their lower scavenging. Nitrated proteins are observed in many cardiovascular, neurodegenerative and inflammatory pathologies. The nitrated proteins can be detected by immunohistochemical methods in situ or detected and identified by chromatography and mass spectrometry.
  • This review summarizes the current knowledge of nitration of tyrosine residues in proteins. Tyrosine residues are nitrated to 3-nitrotyrosine residues by reactive compounds like nitric oxide, nitric dioxide, peroxynitrite and nitrite metabolites as well as by other reactive nitrogen and oxygen species. Peroxynitrites are probably the most important nitration agents in vivo, though other nitrations have also been described. The introduced nitro group influences pKa of the tyrosine residue and its accessibility to phosphorylation as well as protein structure, stability and biological activity. The enhanced nitration of proteins is a consequence of a higher production of reactive nitrogen and oxygen species and/or their lower scavenging. Nitrated proteins are observed in many cardiovascular, neurodegenerative and inflammatory pathologies. The nitrated proteins can be detected by immunohistochemical methods in situ or detected and identified by chromatography and mass spectrometry. (en)
Title
  • Nitrace proteinů reaktivními formami dusíku
  • Nitrace proteinů reaktivními formami dusíku (en)
skos:prefLabel
  • Nitrace proteinů reaktivními formami dusíku
  • Nitrace proteinů reaktivními formami dusíku (en)
skos:notation
  • RIV/61989592:15310/09:00010352!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S, Z(MSM6198959215)
http://linked.open...iv/cisloPeriodika
  • 10
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 329580
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/09:00010352
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • tyrosine nitration; nitric-oxide; mass-spectrometry; peroxynitrite; nitrotyrosine; disease; peptides; phosphorylation; nitrosation; selectivity (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [2EC3B8BA9216]
http://linked.open...i/riv/nazevZdroje
  • Chemické listy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 103
http://linked.open...iv/tvurceVysledku
  • Petřivalský, Marek
  • Luhová, Lenka
  • Hnízdová, Iveta
http://linked.open...n/vavai/riv/zamer
issn
  • 0009-2770
number of pages
http://localhost/t...ganizacniJednotka
  • 15310
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 67 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software