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Description
| - This review summarizes the current knowledge of nitration of tyrosine residues in proteins. Tyrosine residues are nitrated to 3-nitrotyrosine residues by reactive compounds like nitric oxide, nitric dioxide, peroxynitrite and nitrite metabolites as well as by other reactive nitrogen and oxygen species. Peroxynitrites are probably the most important nitration agents in vivo, though other nitrations have also been described. The introduced nitro group influences pKa of the tyrosine residue and its accessibility to phosphorylation as well as protein structure, stability and biological activity. The enhanced nitration of proteins is a consequence of a higher production of reactive nitrogen and oxygen species and/or their lower scavenging. Nitrated proteins are observed in many cardiovascular, neurodegenerative and inflammatory pathologies. The nitrated proteins can be detected by immunohistochemical methods in situ or detected and identified by chromatography and mass spectrometry.
- This review summarizes the current knowledge of nitration of tyrosine residues in proteins. Tyrosine residues are nitrated to 3-nitrotyrosine residues by reactive compounds like nitric oxide, nitric dioxide, peroxynitrite and nitrite metabolites as well as by other reactive nitrogen and oxygen species. Peroxynitrites are probably the most important nitration agents in vivo, though other nitrations have also been described. The introduced nitro group influences pKa of the tyrosine residue and its accessibility to phosphorylation as well as protein structure, stability and biological activity. The enhanced nitration of proteins is a consequence of a higher production of reactive nitrogen and oxygen species and/or their lower scavenging. Nitrated proteins are observed in many cardiovascular, neurodegenerative and inflammatory pathologies. The nitrated proteins can be detected by immunohistochemical methods in situ or detected and identified by chromatography and mass spectrometry. (en)
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Title
| - Nitrace proteinů reaktivními formami dusíku
- Nitrace proteinů reaktivními formami dusíku (en)
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skos:prefLabel
| - Nitrace proteinů reaktivními formami dusíku
- Nitrace proteinů reaktivními formami dusíku (en)
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skos:notation
| - RIV/61989592:15310/09:00010352!RIV10-MSM-15310___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/09:00010352
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - tyrosine nitration; nitric-oxide; mass-spectrometry; peroxynitrite; nitrotyrosine; disease; peptides; phosphorylation; nitrosation; selectivity (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Petřivalský, Marek
- Luhová, Lenka
- Hnízdová, Iveta
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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