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  • This work represents a continuation of our systematic research of transition metal complexes with N6-benzyadenine derivatives. It deals with synthesis, characterization and in vitro cytotoxicity of the platinum(II) and palldium(II) oxalato complexes of the general formula [Pt(L)2(ox)] and [Pd(L)2(ox)], where L stands for a molecule of the cyclin-dependent kinase (CDK) inhibitor of N6-benzyl-9-isopropyladenine moiety. The complexes have been synthesized by a reaction of K2[M(ox)2].2H2O (M = Pt or Pd) with two molar equivalents of the appropriate L organic compounds. The prepared complexes have been fully characterized by varied methods including multinuclear NMR spectroscopy and single-crystal X ray analysis. The geometry of complexes is square planar with tetra-coordinated central transition metal ion and PtN2O2/PdN2O2 donor set. Two L molecules are coordinated through N7 atoms of thein purine moieties. Some of the complexes have shown significant in vitro cytotoxic properties against selected human
  • This work represents a continuation of our systematic research of transition metal complexes with N6-benzyadenine derivatives. It deals with synthesis, characterization and in vitro cytotoxicity of the platinum(II) and palldium(II) oxalato complexes of the general formula [Pt(L)2(ox)] and [Pd(L)2(ox)], where L stands for a molecule of the cyclin-dependent kinase (CDK) inhibitor of N6-benzyl-9-isopropyladenine moiety. The complexes have been synthesized by a reaction of K2[M(ox)2].2H2O (M = Pt or Pd) with two molar equivalents of the appropriate L organic compounds. The prepared complexes have been fully characterized by varied methods including multinuclear NMR spectroscopy and single-crystal X ray analysis. The geometry of complexes is square planar with tetra-coordinated central transition metal ion and PtN2O2/PdN2O2 donor set. Two L molecules are coordinated through N7 atoms of thein purine moieties. Some of the complexes have shown significant in vitro cytotoxic properties against selected human (en)
Title
  • Platinum(II) and palladium(II) oxalato complexes involving N6-benzyladenine-based CDK-inhibitors
  • Platinum(II) and palladium(II) oxalato complexes involving N6-benzyladenine-based CDK-inhibitors (en)
skos:prefLabel
  • Platinum(II) and palladium(II) oxalato complexes involving N6-benzyladenine-based CDK-inhibitors
  • Platinum(II) and palladium(II) oxalato complexes involving N6-benzyladenine-based CDK-inhibitors (en)
skos:notation
  • RIV/61989592:15310/09:00010070!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM6198959218)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 333632
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/09:00010070
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Palladium(II) and Platinum(II) complexes; In vitro cytotoxicity (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • JP - Japonsko
http://linked.open...ontrolniKodProRIV
  • [E4A685E511B6]
http://linked.open...i/riv/nazevZdroje
  • Journal of Biological Inorganic Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 14
http://linked.open...iv/tvurceVysledku
  • Trávníček, Zdeněk
  • Štarha, Pavel
  • Popa, Igor
http://linked.open...n/vavai/riv/zamer
issn
  • 0949-8257
number of pages
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  • 15310
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