About: Oncogenic Kinase Bcr-Abl and Its Resistance to Pharmacological Inhibitors

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The advances in Understanding of neoplastic transformation considerably help the design of molecular-targeted therapies. Protein kinases are critical components of cellular signalling pathways and, due to their frequent deregulation in cancer cells, they have become one of the most important targets in drug development. The efficiency of imatinib in the treatment of chronic myeloid leukemia is a strong evidence that kinase inhibitors can be effective drugs, although some patients develop resistance to them. The structure-based design, however. allows synthesis of second-generation drugs, which are able to overcome this resistance. The review focuses on oncogenic Bcr-Abl its an example of it rational target for kinase inhibitors, their development and biochemical properties. The advances in Understanding of neoplastic transformation considerably help the design of molecular-targeted therapies. Protein kinases are critical components of cellular signalling pathways and, due to their frequent deregulation in cancer cells, they have become one of the most important targets in drug development. The efficiency of imatinib in the treatment of chronic myeloid leukemia is a strong evidence that kinase inhibitors can be effective drugs, although some patients develop resistance to them. The structure-based design, however. allows synthesis of second-generation drugs, which are able to overcome this resistance. The review focuses on oncogenic Bcr-Abl its an example of it rational target for kinase inhibitors, their development and biochemical properties. (en)
Title	Oncogenic Kinase Bcr-Abl and Its Resistance to Pharmacological Inhibitors Oncogenic Kinase Bcr-Abl and Its Resistance to Pharmacological Inhibitors (en)
skos:prefLabel	Oncogenic Kinase Bcr-Abl and Its Resistance to Pharmacological Inhibitors Oncogenic Kinase Bcr-Abl and Its Resistance to Pharmacological Inhibitors (en)
skos:notation	RIV/61989592:15310/08:00010652!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z50380511), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kryštof, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	384832
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/08:00010652
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	imatinib; leukemia; drug; mutant; domain; induction; mutation; complex; VX-680; ST1571 (en)
http://linked.open.../riv/klicoveSlovo	mutant leukemia domain complex mutation drug induction imatinib ST1571 VX-680
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[F33C32D1A70C]
http://linked.open...i/riv/nazevZdroje	Chemické listy
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	1 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	102
http://linked.open...iv/tvurceVysledku	Kryštof, Vladimír
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0009-2770
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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