About: Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase

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About: Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Sister chromatids are held together by the ring-shaped cohesin complex, which likely entraps both DNA- double strands in its middle. This tie is resolved in anaphase when separase, a giant protease, becomes active and cleaves the kleisin subunit of cohesin. Premature activation of separase and, hence, chromosome missegregation are prevented by at least two inhibitory mechanisms. Although securin has long been appreciated as a direct inhibitor of separase, surprisingly its loss has basically no phenotype in mammals. Phosphorylation-dependent binding of Cdk1 constitutes an alternative way to inhibit vertebrate separase. Its importance is illustrated by the premature loss of cohesion when Cdk1-resistant separase is expressed in mammalian cells without or with limiting amounts of securin. Here, we demonstrate that crucial inhibitory phosphorylations occur within a region of human separase that is also shown to make direct contact with the cyclin B1 subunit of Cdk1. This region exhibits a weak homology to Sister chromatids are held together by the ring-shaped cohesin complex, which likely entraps both DNA- double strands in its middle. This tie is resolved in anaphase when separase, a giant protease, becomes active and cleaves the kleisin subunit of cohesin. Premature activation of separase and, hence, chromosome missegregation are prevented by at least two inhibitory mechanisms. Although securin has long been appreciated as a direct inhibitor of separase, surprisingly its loss has basically no phenotype in mammals. Phosphorylation-dependent binding of Cdk1 constitutes an alternative way to inhibit vertebrate separase. Its importance is illustrated by the premature loss of cohesion when Cdk1-resistant separase is expressed in mammalian cells without or with limiting amounts of securin. Here, we demonstrate that crucial inhibitory phosphorylations occur within a region of human separase that is also shown to make direct contact with the cyclin B1 subunit of Cdk1. This region exhibits a weak homology to (en)
Title	Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase (en)
skos:prefLabel	Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase Phosphorylation-dependent binding of cyclin B1 to a Cdc6-like domain of human separase (en)
skos:notation	RIV/61989592:15310/08:00010598!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Lenobel, René
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	386513
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/08:00010598
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sister-chromatid cohesion; Escherichia-Coli; Xenopus-oocytes; meiosis-I; complex; securin; protein; progression; inhibition; anaphase (en)
http://linked.open.../riv/klicoveSlovo	progression Escherichia-Coli inhibition protein complex anaphase Xenopus-oocytes meiosis-I securin sister-chromatid cohesion
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[622E50F9B9E5]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	283
http://linked.open...iv/tvurceVysledku	Lenobel, René Boos, Dominik Koerner, Roman Kuffer, Christian Stemmann, Olaf
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0021-9258
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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