About: Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The synthesis of a new group of 2-X-6-anilinopurines, including compounds with potential cytokinin-like activities, with various substitutions (X = H, halogen, amino, methylthio or nitro) on the phenyl ring is described. The prepared compounds have been characterized using standard physico-chemical methods, and the influence of individual substituents on biological activity has been compared in three different bioassays, based on the stimulation of tobacco callus growth, retention of chlorophyll in excised wheat leaves and the dark induction of betacyanin synthesis in Amaranthus cotyledons. The biological activity of the prepared compounds was also assessed in receptor assays, in which the ability of the compounds to activate the cytokinin receptors AHK3 and AHK4/CRE1 was studied. Finally, the interactions of the compounds with the Arabidopsis cytokinin oxidase/dehydrogenase AtCKX2 (heterologously expressed) were investigated. Systematic testing led to the identification of two very potent inhibitors The synthesis of a new group of 2-X-6-anilinopurines, including compounds with potential cytokinin-like activities, with various substitutions (X = H, halogen, amino, methylthio or nitro) on the phenyl ring is described. The prepared compounds have been characterized using standard physico-chemical methods, and the influence of individual substituents on biological activity has been compared in three different bioassays, based on the stimulation of tobacco callus growth, retention of chlorophyll in excised wheat leaves and the dark induction of betacyanin synthesis in Amaranthus cotyledons. The biological activity of the prepared compounds was also assessed in receptor assays, in which the ability of the compounds to activate the cytokinin receptors AHK3 and AHK4/CRE1 was studied. Finally, the interactions of the compounds with the Arabidopsis cytokinin oxidase/dehydrogenase AtCKX2 (heterologously expressed) were investigated. Systematic testing led to the identification of two very potent inhibitors (en)
Title	Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase (en)
skos:prefLabel	Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase (en)
skos:notation	RIV/61989592:15310/08:00010328!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M06030), P(GA206/07/0570), P(GA522/06/0108), P(LC06034), Z(AV0Z50380511), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	20
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Spíchal, Lukáš Zatloukal, Marek Havlíček, Libor Doležal, Karel Strnad, Miroslav Gemrotová, Markéta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	383281
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/08:00010328
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytokinins; 6-anilinopurines; cytokinin oxidase/dehydrogenase (en)
http://linked.open.../riv/klicoveSlovo	cytokinin oxidase/dehydrogenase cytokinins 6-anilinopurines
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[FA4E79F36DB2]
http://linked.open...i/riv/nazevZdroje	Bioorganic & Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Regulation of morphogenesis of plant cells and organs New cytokinin derivatives in plants: isolation, identification and biological activity Functional genomics and proteomics for crop improvement Influence of new 6-benzylaminopurine derivatives on micropropagation of selected broad-leaved forest tree species
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Doležal, Karel Havlíček, Libor Strnad, Miroslav Spíchal, Lukáš Zatloukal, Marek Gemrotová, Markéta
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0968-0896
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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