About: Brassinosteroids: Synthesis and Activity of Some Fluoro Analogues     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • Three types of 5alpha-androstane and ergostane analogs of brassinolide, containing a fluorine atom in either the 3alpha or the 5alpha positions or in 3alpha and 5alpha positions were prepared using standard operations (reaction of 3beta-alcohols with (diethylamino)sulfur trifluoride, cleavage of epoxide with HF in py or BF3.Et2O). The 5alpha-fluorine was found to affect chemical reactivity (eg electrophilic addition to the Δ2-double bond) as well as physical properties (eg NMR, chromatographic behavior) of the products. Cytotoxic activity of the products was studied using human normal and cancer cell lines with 28-homocastasterone as positive control, their brassinolide type activity was established using the bean second-internode test with 24-epibrassinolide as standard. The equivalence of F and OH groups was observed in some of the active compounds. The anticancer and the brassinolide-type activity do not correlate with each other: ergostane derivatives were most active in the former test while
  • Three types of 5alpha-androstane and ergostane analogs of brassinolide, containing a fluorine atom in either the 3alpha or the 5alpha positions or in 3alpha and 5alpha positions were prepared using standard operations (reaction of 3beta-alcohols with (diethylamino)sulfur trifluoride, cleavage of epoxide with HF in py or BF3.Et2O). The 5alpha-fluorine was found to affect chemical reactivity (eg electrophilic addition to the Δ2-double bond) as well as physical properties (eg NMR, chromatographic behavior) of the products. Cytotoxic activity of the products was studied using human normal and cancer cell lines with 28-homocastasterone as positive control, their brassinolide type activity was established using the bean second-internode test with 24-epibrassinolide as standard. The equivalence of F and OH groups was observed in some of the active compounds. The anticancer and the brassinolide-type activity do not correlate with each other: ergostane derivatives were most active in the former test while (en)
Title
  • Brassinosteroids: Synthesis and Activity of Some Fluoro Analogues
  • Brassinosteroids: Synthesis and Activity of Some Fluoro Analogues (en)
skos:prefLabel
  • Brassinosteroids: Synthesis and Activity of Some Fluoro Analogues
  • Brassinosteroids: Synthesis and Activity of Some Fluoro Analogues (en)
skos:notation
  • RIV/61989592:15310/08:00009943!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(IAA400550609), Z(AV0Z40550506), Z(AV0Z50380511), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 13
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 358464
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/08:00009943
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • brassinolide; i-steroids; DAST; 1H NMR spectroscopy; metabolic stability; Calcein-AM; cytotoxicity assay; bean second-internode bioassay (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [BA63E56843E9]
http://linked.open...i/riv/nazevZdroje
  • Journal of Medicinal Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 51
http://linked.open...iv/tvurceVysledku
  • Buděšínský, Miloš
  • Kohout, Ladislav
  • Oklešťková, Jana
  • Slavíková, Barbora
  • Kasal, Alexandr
http://linked.open...n/vavai/riv/zamer
issn
  • 0022-2623
number of pages
http://localhost/t...ganizacniJednotka
  • 15310
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software