Attributes | Values |
---|
rdf:type
| |
Description
| - Three types of 5alpha-androstane and ergostane analogs of brassinolide, containing a fluorine atom in either the 3alpha or the 5alpha positions or in 3alpha and 5alpha positions were prepared using standard operations (reaction of 3beta-alcohols with (diethylamino)sulfur trifluoride, cleavage of epoxide with HF in py or BF3.Et2O). The 5alpha-fluorine was found to affect chemical reactivity (eg electrophilic addition to the Δ2-double bond) as well as physical properties (eg NMR, chromatographic behavior) of the products. Cytotoxic activity of the products was studied using human normal and cancer cell lines with 28-homocastasterone as positive control, their brassinolide type activity was established using the bean second-internode test with 24-epibrassinolide as standard. The equivalence of F and OH groups was observed in some of the active compounds. The anticancer and the brassinolide-type activity do not correlate with each other: ergostane derivatives were most active in the former test while
- Three types of 5alpha-androstane and ergostane analogs of brassinolide, containing a fluorine atom in either the 3alpha or the 5alpha positions or in 3alpha and 5alpha positions were prepared using standard operations (reaction of 3beta-alcohols with (diethylamino)sulfur trifluoride, cleavage of epoxide with HF in py or BF3.Et2O). The 5alpha-fluorine was found to affect chemical reactivity (eg electrophilic addition to the Δ2-double bond) as well as physical properties (eg NMR, chromatographic behavior) of the products. Cytotoxic activity of the products was studied using human normal and cancer cell lines with 28-homocastasterone as positive control, their brassinolide type activity was established using the bean second-internode test with 24-epibrassinolide as standard. The equivalence of F and OH groups was observed in some of the active compounds. The anticancer and the brassinolide-type activity do not correlate with each other: ergostane derivatives were most active in the former test while (en)
|
Title
| - Brassinosteroids: Synthesis and Activity of Some Fluoro Analogues
- Brassinosteroids: Synthesis and Activity of Some Fluoro Analogues (en)
|
skos:prefLabel
| - Brassinosteroids: Synthesis and Activity of Some Fluoro Analogues
- Brassinosteroids: Synthesis and Activity of Some Fluoro Analogues (en)
|
skos:notation
| - RIV/61989592:15310/08:00009943!RIV10-MSM-15310___
|
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| - P(IAA400550609), Z(AV0Z40550506), Z(AV0Z50380511), Z(MSM6198959216)
|
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/08:00009943
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - brassinolide; i-steroids; DAST; 1H NMR spectroscopy; metabolic stability; Calcein-AM; cytotoxicity assay; bean second-internode bioassay (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
|
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| - Journal of Medicinal Chemistry
|
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...vavai/riv/projekt
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Buděšínský, Miloš
- Kohout, Ladislav
- Oklešťková, Jana
- Slavíková, Barbora
- Kasal, Alexandr
|
http://linked.open...n/vavai/riv/zamer
| |
issn
| |
number of pages
| |
http://localhost/t...ganizacniJednotka
| |