About: Nano-desorption electrospray and kinetic method in chiral analysis of drugs in whole human blood samples

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A home-made nano-desorption electrospray ionization (nano-DESI) device and the kinetic method were tested in chiral analysis of model clinical samples containing enantiomers of one of three pharmaceutically important compounds: dihydroxyphenylalanine (DOPA), ephedrine and ibuprofen. The initial evaluation of chiral systems was carried out by direct infusion of solution mixtures (analyte/central metal/chiral reference ligand) to a standard electrospray ionization (ESI) source. Cu(II) was used as a central metal for all. analytes, L-phenylalanine was applied as a chiral reference ligand for DOPA, whereas L-tryptophan was used for the other two analytes. Then, the ESI source was substituted by a nano-DESI source and dried spots of 1 mu L samples of whole human blood spiked with individual drugs were successfully analyzed without any pre-treatment. Irrespective of a laborious initial nano-DESI set-up, the combination of the kinetic method with nano-desorption electrospray has, for the first time, been dem A home-made nano-desorption electrospray ionization (nano-DESI) device and the kinetic method were tested in chiral analysis of model clinical samples containing enantiomers of one of three pharmaceutically important compounds: dihydroxyphenylalanine (DOPA), ephedrine and ibuprofen. The initial evaluation of chiral systems was carried out by direct infusion of solution mixtures (analyte/central metal/chiral reference ligand) to a standard electrospray ionization (ESI) source. Cu(II) was used as a central metal for all. analytes, L-phenylalanine was applied as a chiral reference ligand for DOPA, whereas L-tryptophan was used for the other two analytes. Then, the ESI source was substituted by a nano-DESI source and dried spots of 1 mu L samples of whole human blood spiked with individual drugs were successfully analyzed without any pre-treatment. Irrespective of a laborious initial nano-DESI set-up, the combination of the kinetic method with nano-desorption electrospray has, for the first time, been dem (en)
Title	Nano-desorption electrospray and kinetic method in chiral analysis of drugs in whole human blood samples Nano-desorption electrospray and kinetic method in chiral analysis of drugs in whole human blood samples (en)
skos:prefLabel	Nano-desorption electrospray and kinetic method in chiral analysis of drugs in whole human blood samples Nano-desorption electrospray and kinetic method in chiral analysis of drugs in whole human blood samples (en)
skos:notation	RIV/61989592:15310/08:00005427!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA203/07/0765), S, Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Lemr, Karel Bednář, Petr Havlíček, Vladimír Ranc, Václav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	381594
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/08:00005427
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nano-desorption electrospray; mass spectrometry; kinetic method; chiral analysis; drug analysis; human blood samples (en)
http://linked.open.../riv/klicoveSlovo	mass spectrometry kinetic method chiral analysis drug analysis human blood samples nano-desorption electrospray
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2087044EC651]
http://linked.open...i/riv/nazevZdroje	European Journal of Mass Spectrometry
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of isomers by mass spectrometry and kinetic method
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Bednář, Petr Lemr, Karel Havlíček, Vladimír Ranc, Václav
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	1469-0667
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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