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| Description
| - Mnozí členové nadrodiny cytochromu P450 (CYP) jsou inducibilní po expozici různým xenobiotikům v lidských játrech. Dosáhli jsme značných mechanistických poznatků těchto dějů v hepatocytech a několik ligandy-aktivovaných transkripčních faktorů bylo identifikováno v uplynulých dvou desetiletích. Rodiny CYP1, CYP2 a CYP3 zapojené do metabolismu xenobiotik jsou rovněž exprimovány v extrahepatálních tkáních (např. střevě, mozku, ledvinách, placentě, plících, nadledvinkách, slinivce, kůži, mléčné žláze, děloze, vaječnících, varlatech a prostatě). Jelikož exprese většiny Isidorem se jeví býti velmi nízká v extrahepatálních tkáních ve srovnání s expresí v játrech dospělého člověka, úloha těchto enzymů v úhrnném metabolismu a celkové clearance je minoritní. Nicméně, bazální exprese a up-regulace extrahepatálních CYP enzymů může významně ovlivnit místní distribuci xenobiotika nebo endogenní sloučeniny v periferních tkáních a takto modifikovat jejich farmakologické/toxikologické účinky nebo ovlivnit absorpci xen (cs)
- Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights into these processes in hepatocytes and multiple ligand-activated transcription factors have been identified over the past two decades. Families CYP1, CYP2 and CYP3 involved in xenobiotic metabolism are also expressed in a range of extrahepatic tissues (e.g. intestine, brain, kidney, placenta, lung, adrenal gland, pancreas, skin, mammary gland, uterus, ovary, testes and prostate). Since the expression of the majority of the isoforms appears to be very low in the extrahepatic tissues in comparison with predominant expression in adult liver, the role of the enzymes in overall biotransformation and total body clearance is minor. However, basal expression and up-regulation of extrahepatic CYP enzymes can significantly affect local disposition of xenobiotics or endogenous compounds in peripheral tissues and thus modify their
- Numerous members of the cytochrome P450 (CYP) superfamily are induced after exposure to a variety of xenobiotics in human liver. We have gained considerable mechanistic insights into these processes in hepatocytes and multiple ligand-activated transcription factors have been identified over the past two decades. Families CYP1, CYP2 and CYP3 involved in xenobiotic metabolism are also expressed in a range of extrahepatic tissues (e.g. intestine, brain, kidney, placenta, lung, adrenal gland, pancreas, skin, mammary gland, uterus, ovary, testes and prostate). Since the expression of the majority of the isoforms appears to be very low in the extrahepatic tissues in comparison with predominant expression in adult liver, the role of the enzymes in overall biotransformation and total body clearance is minor. However, basal expression and up-regulation of extrahepatic CYP enzymes can significantly affect local disposition of xenobiotics or endogenous compounds in peripheral tissues and thus modify their (en)
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| Title
| - Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues
- Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues (en)
- Xenobiotiky-indukovaná transkripční regulace xenobiotika-metabolizujících enzymů z rodiny cytochromu P450 v lidských extrahepatálních tkáních (cs)
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| skos:prefLabel
| - Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues
- Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues (en)
- Xenobiotiky-indukovaná transkripční regulace xenobiotika-metabolizujících enzymů z rodiny cytochromu P450 v lidských extrahepatálních tkáních (cs)
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| skos:notation
| - RIV/61989592:15310/08:00005342!RIV09-MSM-15310___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA303/07/0128), S, Z(MSM6198959216)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/08:00005342
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Transcriptional regulation; cytochrome P450; extrahepatic; xenobiotics; metabolism; intestine; lung; kidney. (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Dvořák, Zdeněk
- Pávek, Petr
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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