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| rdf:type
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| Description
| - Lidská populace je stale vice vystavena množství environmentálních polutantů jako jsou polycyklické aromatické uhlovodíky, polychlorované bifenyly a dioxiny. Tyto sloučeniny jsou aktivátory aryl uhlovodíkového receptoru (AhR), které řídí expresi mnoha genů včetně detoxikačních enzymů. Regulační mechanismy AhR jsou multi-faktoriální a zahrnují fosforylaci nejrůznějšími kinasami. Signifikantní progress ve výzkumu mitogeny-aktivovaných protein kinas (MAPKs) byl učiněn v uplynulém desetiletí. O úloze MAPKs ve funci AhR a vice versa byla publikována ojedinělá sdělení, kdy byla pozorována aktivace MAPKs ligandy AhR. Toto mini-review sumarizuje současné znalosti o vzájemných interakcích mezi MAPKs a AhR. Většina studií byla provedena v nádorových liniích, které vykazují dysregulaci buněčného cyklu, a postrádají detoxikační aparát. Zdůrazňujeme důležitost studií prováděných v netransformovaných buňkách, aby bylo možno odlišit úlohu MAPKs v nádorové a normální buňce. Jak ukázaly naše experimenty, modelem volby (cs)
- Human populations are increasingly exposed to a number of environmental pollutants such as polycyclic aromatic hydrocarbons, polychlorinated biphenyls and dioxins. These compounds are activators of the aryl hydrocarbon receptor (AhR) that controls the expression of many genes including those for detoxification enzymes. The regulatory mechanisms of AhR are multi-factorial and include phosphorylation by various protein kinases. Significant progress in the research of mitogen-activated protein kinases (MAPKs) has been achieved in the last decade. Isolated reports have been published on the role of MAPKs in AhR functions and vice versa, with activation of MAPKs by AhR ligands. This mini-review summarizes current knowledge on the mutual interactions between MAPKs and AhR. The majority of studies has been done on cancer-derived cell lines that have impaired cell cycle regulation and lacks the complete detoxification apparatus. We emphasize the importance of the future studies that should be done on non-tran
- Human populations are increasingly exposed to a number of environmental pollutants such as polycyclic aromatic hydrocarbons, polychlorinated biphenyls and dioxins. These compounds are activators of the aryl hydrocarbon receptor (AhR) that controls the expression of many genes including those for detoxification enzymes. The regulatory mechanisms of AhR are multi-factorial and include phosphorylation by various protein kinases. Significant progress in the research of mitogen-activated protein kinases (MAPKs) has been achieved in the last decade. Isolated reports have been published on the role of MAPKs in AhR functions and vice versa, with activation of MAPKs by AhR ligands. This mini-review summarizes current knowledge on the mutual interactions between MAPKs and AhR. The majority of studies has been done on cancer-derived cell lines that have impaired cell cycle regulation and lacks the complete detoxification apparatus. We emphasize the importance of the future studies that should be done on non-tran (en)
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| Title
| - Role of mitogen-activated protein kinases in aryl hydrocarbon receptor signaling.
- Role of mitogen-activated protein kinases in aryl hydrocarbon receptor signaling. (en)
- Úloha mitogeny-aktivovaných protein kinas v signalizaci aryl uhlovodíkovým receptorem. (cs)
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| skos:prefLabel
| - Role of mitogen-activated protein kinases in aryl hydrocarbon receptor signaling.
- Role of mitogen-activated protein kinases in aryl hydrocarbon receptor signaling. (en)
- Úloha mitogeny-aktivovaných protein kinas v signalizaci aryl uhlovodíkovým receptorem. (cs)
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| skos:notation
| - RIV/61989592:15310/08:00005341!RIV09-MSM-15310___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA303/07/0128), Z(MSM6198959216)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/08:00005341
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Aryl hydrocarbon receptor; MAPK; JNK/SAPK; p38; ERK; Cell signaling (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Chemico-Biological Interactions
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Dvořák, Zdeněk
- Ulrichová, Jitka
- Vrzal, Radim
- Henklová, Pavla
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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