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| Description
| - Série platičitých komplexů s cytokininy nebo inhibitory CDK odvozenými 6-benzylaminopurinu (Bap) o složení [Pt-IV(LH+)Cl-5] (1-14), kde LH+ je protonizovaná forma derivátu bap (1-12), Boh = 6-(benzylamino)-2-[(3-hydroxypropyl)amino]-9-isopropylpurin, bohemin (13) a Ros = 6-(benzylamino)-2-[(1-hydroxymethylpropyl)amino]-9-izopropylpurin, roskovitin (14), byly připraveny a plně charakterizovány pomocí mikroanalýzy, vodivostních měření, FT-IR, H-1, C-13, N-15 a Pt-195 NMR a ES+ hmotnostní spektrometrií. Všechny sloučeniny byly testovány in vitro na cytotoxicitu na čtyřech lidských nádorových liniích. Molekulové struktury dvou iontových sloučenin (BohH)(2)(2+))[PtCl6].H2O a (RosH(2)(2+))(2)[PtCl6]Cl2.4H2O byly určeny pomocí monokrystalové rentgenostrukturní analýzy. (cs)
- A series of Pt(IV) complexes with cytokinins or CDK-inhibitors derived from 6-benzylaminopurine (Bap) of the composition [Pt-IV(LH+)Cl-5] (1-14), where LH+ stands for protonated form of the bap derivate (1-12), Boh = 6-(benzylamino)-2-[(3-hydroxypropyl)amino]-9-isopropylpurine, bohemine (13) and Ros = 6-(benzylamino)-2-[(1-hydroxymethylpropyl)amino]-9-isopropylpurine, roscovitine (14), have been prepared. They have been fully characterized by microanalysis, conductivity, FT-IR, H-1, C-13, N-15 and Pt-195 NMR and ES+ mass spectroscopy. All of the compounds have been tested in vitro for their cytotoxicity against four human cancer cell lines. The molecular structures of two ionic pair compounds (BohH)(2)(2+))[PtCl6].H2O and (RosH(2)(2+))(2)[PtCl6]Cl2.4H2O have been determined by a single crystal X-raz analysis.
- A series of Pt(IV) complexes with cytokinins or CDK-inhibitors derived from 6-benzylaminopurine (Bap) of the composition [Pt-IV(LH+)Cl-5] (1-14), where LH+ stands for protonated form of the bap derivate (1-12), Boh = 6-(benzylamino)-2-[(3-hydroxypropyl)amino]-9-isopropylpurine, bohemine (13) and Ros = 6-(benzylamino)-2-[(1-hydroxymethylpropyl)amino]-9-isopropylpurine, roscovitine (14), have been prepared. They have been fully characterized by microanalysis, conductivity, FT-IR, H-1, C-13, N-15 and Pt-195 NMR and ES+ mass spectroscopy. All of the compounds have been tested in vitro for their cytotoxicity against four human cancer cell lines. The molecular structures of two ionic pair compounds (BohH)(2)(2+))[PtCl6].H2O and (RosH(2)(2+))(2)[PtCl6]Cl2.4H2O have been determined by a single crystal X-raz analysis. (en)
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| Title
| - The first platinum(IV) complexes involving aromatic cytokinins or cyclic-dependent kinase inhibitors derived from 6-benzylaminopurine: X-ray structures of (BohH(2)(2+))[PtCl6].H2O and (RosH(2)(2+)(2)[PtCl6]Cl2.4H2O
- The first platinum(IV) complexes involving aromatic cytokinins or cyclic-dependent kinase inhibitors derived from 6-benzylaminopurine: X-ray structures of (BohH(2)(2+))[PtCl6].H2O and (RosH(2)(2+)(2)[PtCl6]Cl2.4H2O (en)
- První platičité komplexy obsahující aromatické cytokininy nebo inhibitory cyklin-dependentních kináz odvozené od 6-benzylaminopurinu: Molekulové struktury (BohH(2)(2+))[PtCl6].H2O a (RosH(2)(2+)(2)[PtCl6]Cl2.4H2O (cs)
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| skos:prefLabel
| - The first platinum(IV) complexes involving aromatic cytokinins or cyclic-dependent kinase inhibitors derived from 6-benzylaminopurine: X-ray structures of (BohH(2)(2+))[PtCl6].H2O and (RosH(2)(2+)(2)[PtCl6]Cl2.4H2O
- The first platinum(IV) complexes involving aromatic cytokinins or cyclic-dependent kinase inhibitors derived from 6-benzylaminopurine: X-ray structures of (BohH(2)(2+))[PtCl6].H2O and (RosH(2)(2+)(2)[PtCl6]Cl2.4H2O (en)
- První platičité komplexy obsahující aromatické cytokininy nebo inhibitory cyklin-dependentních kináz odvozené od 6-benzylaminopurinu: Molekulové struktury (BohH(2)(2+))[PtCl6].H2O a (RosH(2)(2+)(2)[PtCl6]Cl2.4H2O (cs)
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| skos:notation
| - RIV/61989592:15310/07:00004798!RIV08-MSM-15310___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/07:00004798
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Olomoucine; Bohemine; Platinum(IV) (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Herchel, Radovan
- Marek, Jaromír
- Trávníček, Zdeněk
- Popa, Igor
- Čajan, Michal
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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