About: The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest.

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About: The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Alteration of cyclin-dependent kinases (CDK) in cancer has stimulated the search of molecules targeting CDK activity as anticancer agents. We previously reported the inhibition of CDK1 and CDK2 activity by plant cytokinin analogues. These compounds inhibit proliferation and induce apoptosis, that is initiated by nmitochondrial pathway. In this study, the mechanism of CDK inhibitor-induced apoptosis and the effect on cell cycle distribution were further investigated. Alteration of cyclin-dependent kinases (CDK) in cancer has stimulated the search of molecules targeting CDK activity as anticancer agents. We previously reported the inhibition of CDK1 and CDK2 activity by plant cytokinin analogues. These compounds inhibit proliferation and induce apoptosis, that is initiated by nmitochondrial pathway. In this study, the mechanism of CDK inhibitor-induced apoptosis and the effect on cell cycle distribution were further investigated. (en)
Title	The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest. The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest. (en)
skos:prefLabel	The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest. The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest. (en)
skos:notation	RIV/61989592:15310/06:00010621!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6198959216)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Havlíček, Libor Strnad, Miroslav
http://linked.open.../riv/druhVysledku	C - Kapitola v knize
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	465563
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/06:00010621
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytokinins; cyclin-dependent kinases; cell cycle; antiproliferative effects (en)
http://linked.open.../riv/klicoveSlovo	antiproliferative effects cell cycle cytokinins cyclin-dependent kinases
http://linked.open...ontrolniKodProRIV	[08B12E6B625B]
http://linked.open...i/riv/nazevZdroje	Essays on Phytohormones and Signalling in Plants
http://linked.open...in/vavai/riv/obor	EI
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...v/pocetStranKnihy	363 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...UplatneniVysledku	2006
http://linked.open...iv/tvurceVysledku	Havlíček, Libor Strnad, Miroslav Vermeulen, Katrien Berneman, Zwi Venken, Thomas van Bockstaele, Dirk van Onckelen, Henri
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
number of pages	9 (xsd:int)
http://purl.org/ne...btex#hasPublisher	University of Antwerp
https://schema.org/isbn	90-5728-067-1
http://localhost/t...ganizacniJednotka	15310

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