About: Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats

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About: Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The subchronic safety of sanguiritrin, a mixture of sanguinarine ( SA) and chelerythrine (CHE) quaternary benzo[c] phenanthridine alkaloids (QBA), obtained from Macleaya cordata was assessed. Rats were fed a diet containing 120 ppm sanguiritrin ( 100 ppm QBA) for 109 days. The feed consumption and the animal weight were monitored. The content of QBA in selected tissues and plasma was determined using HPLC. It was evidenced that 2% of QBA were absorbed through the GIT while 98% were excreted in the feces. In plasma, bilirubin, urea, creatinine, glomerular filtration, AST, ALT, GMT, ALP and total antioxidant capacity were determined. In liver, GSH level, lipoperoxidation products, SOD and GPx activities and total amount of cytochrome P450 were evaluated. Damage to nuclear DNA was assessed; a P-32-postlabeling assay proved that no DNA-adducts were detected in nuclear and mitochrondrial DNA in liver. No adverse effects were observed on rat organism. QBA had no influence on the gut mucosal epithelium, live The subchronic safety of sanguiritrin, a mixture of sanguinarine ( SA) and chelerythrine (CHE) quaternary benzo[c] phenanthridine alkaloids (QBA), obtained from Macleaya cordata was assessed. Rats were fed a diet containing 120 ppm sanguiritrin ( 100 ppm QBA) for 109 days. The feed consumption and the animal weight were monitored. The content of QBA in selected tissues and plasma was determined using HPLC. It was evidenced that 2% of QBA were absorbed through the GIT while 98% were excreted in the feces. In plasma, bilirubin, urea, creatinine, glomerular filtration, AST, ALT, GMT, ALP and total antioxidant capacity were determined. In liver, GSH level, lipoperoxidation products, SOD and GPx activities and total amount of cytochrome P450 were evaluated. Damage to nuclear DNA was assessed; a P-32-postlabeling assay proved that no DNA-adducts were detected in nuclear and mitochrondrial DNA in liver. No adverse effects were observed on rat organism. QBA had no influence on the gut mucosal epithelium, live (en)
Title	Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats (en)
skos:prefLabel	Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats Safety assessment of sanguiritrin, alkaloid fraction of Macleaya cordata, in rats (en)
skos:notation	RIV/61989592:15310/06:00003049!RIV10-MSM-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP203/03/D237), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Lichnovský, Václav Šimánek, Vilím VEČEŘA, Rostislav VIČAR, Jaroslav Rajnochová Svobodová, Alena Ulrichová, Jitka Galandáková, Adéla Hrbáč, Jan Kosina, Pavel Jirovský, David Anzenbacherová, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	498353
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/06:00003049
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	benzo[c]phenanthridine alkaloids; oral administration; biochemical markers; oxidative stress; DNA damage; cytochrome P450 (en)
http://linked.open.../riv/klicoveSlovo	biochemical markers benzo[c]phenanthridine alkaloids DNA damage cytochrome P450 oxidative stress oral administration
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3D732B7471BE]
http://linked.open...i/riv/nazevZdroje	Veterinární medicína
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	11 (xsd:int)
http://linked.open...cetTvurcuVysledku	13 (xsd:int)
http://linked.open...vavai/riv/projekt	Analysis of natural antioxidants using HPLC with coulometric detection
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Kosina, Pavel Ulrichová, Jitka Hrbáč, Jan Anzenbacherová, Eva Šimánek, Vilím Večeřa, Rostislav Jirovský, David Svobodová, Alena Vičar, Jaroslav Lichnovský, Václav Zdařilová, Adéla Stiborová, M. Psotová, Jitka
http://linked.open...n/vavai/riv/zamer	Modulation of signalling and regulatory pathways in normal and cancer cells
issn	0375-8427
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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