About: New cytokinin derivatives for agriculture and medicine

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	New series of cytokinins derived from 6-benzylaminopurine have been developed for agricultural and biotechnological applications. These compounds exhibit very high biological activities in different cytokinin bioassays. The methoxy and fluoro derivatives exhibited 2-10 times higher activity then trans-zeatin and expressed very positive antisenescent and morphogenetic properties in different in vitro cultures. Among aromatic cytokinin derivatives, we have discovered a compound, 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, named %22olomoucine%22 (OC), which specifically inhibits some cyclin-dependent kinases (CDKs) at micromolar concentration. The design and inhibitory activity of OC was further improved by modifications at positions 2, 6, and 9. This has led to development of specific CDK inhibitors like roscovitine, olomoucine II and purvalanol A, which display an enhanced inhibitory activity toward CDK1, a higher selectivity for some CDKs, an increased antimitotic activity at the G1/S and G2/M New series of cytokinins derived from 6-benzylaminopurine have been developed for agricultural and biotechnological applications. These compounds exhibit very high biological activities in different cytokinin bioassays. The methoxy and fluoro derivatives exhibited 2-10 times higher activity then trans-zeatin and expressed very positive antisenescent and morphogenetic properties in different in vitro cultures. Among aromatic cytokinin derivatives, we have discovered a compound, 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, named %22olomoucine%22 (OC), which specifically inhibits some cyclin-dependent kinases (CDKs) at micromolar concentration. The design and inhibitory activity of OC was further improved by modifications at positions 2, 6, and 9. This has led to development of specific CDK inhibitors like roscovitine, olomoucine II and purvalanol A, which display an enhanced inhibitory activity toward CDK1, a higher selectivity for some CDKs, an increased antimitotic activity at the G1/S and G2/M (en) Jsou popsány nové deriváty cytokininů pro zemědělství a medicínu. (cs)
Title	Nové deriváty cytokininů pro zemědělství a medicínu (cs) New cytokinin derivatives for agriculture and medicine New cytokinin derivatives for agriculture and medicine (en)
skos:prefLabel	Nové deriváty cytokininů pro zemědělství a medicínu (cs) New cytokinin derivatives for agriculture and medicine New cytokinin derivatives for agriculture and medicine (en)
skos:notation	RIV/61989592:15310/04:00002278!RIV/2005/GA0/153105/N
http://linked.open.../vavai/riv/strany	76
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA522/01/0275), Z(MSM 153100008)
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Zatloukal, Marek Kryštof, Vladimír Doležal, Karel Strnad, Miroslav Lenobel, René Binarová, Pavla
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	576056
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/04:00002278
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cytokinin;6-benzylaminopurine;olomoucine;bohemine;roscovitine;antitumour effects (en)
http://linked.open.../riv/klicoveSlovo	6-benzylaminopurine bohemine Cytokinin roscovitine antitumour effects olomoucine
http://linked.open...ontrolniKodProRIV	[FAB0F7A1668D]
http://linked.open...i/riv/mistoVydani	Canberra
http://linked.open...i/riv/nazevZdroje	18th IPGSA conference, Conference Handbook
http://linked.open...in/vavai/riv/obor	EF
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of new cytokinin metabolites: isolation, identification and biosynthesis
http://linked.open...UplatneniVysledku	2004
http://linked.open...iv/tvurceVysledku	Binarová, Pavla Doležal, Karel Havlíček, Libor Kryštof, Vladimír Strnad, Miroslav Zatloukal, Marek Popa, Igor Lenobel, René
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20153100008
number of pages	144 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Australian National University
http://localhost/t...ganizacniJednotka	15310

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