About: Enzymatic and Nonenzymatic Dehalogenation of 1,2-chloroethane and 1,2-dibromoethane

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About: Enzymatic and Nonenzymatic Dehalogenation of 1,2-chloroethane and 1,2-dibromoethane Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	1,2-Dichloroethane (DCE) and 1,2-dibromoethane (DBE) are toxic and mutagenic halogenated compounds. As many other synthetic halogenated aliphatic compounds, both are rather resistant to biodegradation and persist in the environment1. Nevertheless, several bacterial cultures that are able to use DCE as the only carbon and halogen source have been isolated. The most efficient catalysis has been observed with the haloalkane dehalogenase DhlA from Xanthobacter autotrophicus GJ10 and substantially low activity with haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT262. A crystallographic analysis of LinB-DCE complex showed non-productive binding of DCE to the enzyme active site, while molecular docking suggested that DCE molecule can possibly bind to the active site but is prevented by chloride ion and/or water molecules3. The different reactivity of DCE and DBE was examined by quantum mechanical calculations as well as by molecular dynamics simulations of enzyme-substrate complexes The calcula 1,2-Dichloroethane (DCE) and 1,2-dibromoethane (DBE) are toxic and mutagenic halogenated compounds. As many other synthetic halogenated aliphatic compounds, both are rather resistant to biodegradation and persist in the environment1. Nevertheless, several bacterial cultures that are able to use DCE as the only carbon and halogen source have been isolated. The most efficient catalysis has been observed with the haloalkane dehalogenase DhlA from Xanthobacter autotrophicus GJ10 and substantially low activity with haloalkane dehalogenase LinB from Sphingomonas paucimobilis UT262. A crystallographic analysis of LinB-DCE complex showed non-productive binding of DCE to the enzyme active site, while molecular docking suggested that DCE molecule can possibly bind to the active site but is prevented by chloride ion and/or water molecules3. The different reactivity of DCE and DBE was examined by quantum mechanical calculations as well as by molecular dynamics simulations of enzyme-substrate complexes The calcula (en) Byla studována enzymatická a neenzymatická dehalogenace 1,2-chloroethanu a 1,2-dibromoethanu. (cs)
Title	Enzymatic and Nonenzymatic Dehalogenation of 1,2-chloroethane and 1,2-dibromoethane Enzymatic and Nonenzymatic Dehalogenation of 1,2-chloroethane and 1,2-dibromoethane (en) Enzymatická a neenzymatická dehalogenace 1,2-chloroethanu a 1,2-dibromoethanu (cs)
skos:prefLabel	Enzymatic and Nonenzymatic Dehalogenation of 1,2-chloroethane and 1,2-dibromoethane Enzymatic and Nonenzymatic Dehalogenation of 1,2-chloroethane and 1,2-dibromoethane (en) Enzymatická a neenzymatická dehalogenace 1,2-chloroethanu a 1,2-dibromoethanu (cs)
skos:notation	RIV/61989592:15310/04:00002220!RIV/2005/MSM/153105/N
http://linked.open.../vavai/riv/strany	261-262
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 153100007)
http://linked.open...iv/cisloPeriodika	Suppl.
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Otyepka, Michal Otyepková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	563008
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/04:00002220
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Dehalogenation;1,2-chloroethane;1,2-dibromoethane (en)
http://linked.open.../riv/klicoveSlovo	1 Dehalogenation 2-chloroethane 2-dibromoethane
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[605ADBE56065]
http://linked.open...i/riv/nazevZdroje	Acta Universitatis Palackianae Olomucensis, Facultas Rerum Naturalium, Chemica
http://linked.open...in/vavai/riv/obor	CF
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	43
http://linked.open...iv/tvurceVysledku	Damborský, Jiří Otyepka, Michal Otyepková, Eva Prokop, Zdeněk Boháč, Michal
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20153100007
issn	0232-0061
number of pages	275 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

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