About: The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest

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About: The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The activity of cyclin-dependent kinases (CDK), the key regulators of the cell cycle, is strictly controlled by different mechanisms but is often altered in human cancer. This has stimulated the search for molecules targeting CDK activity as anti-canceragents. Different types of CDK inhibitors have been described, among them, C2-, N6-, N9-substituted purines such as plant cytokinin analogues. We have previously reported the inhibition of CDK1 and CDK2 activity by a new group of plant cytokinin analogu es (Vermeulen et al., Leukemia 2001;16:299). These compounds inhibit proliferation of leukemic cell lines and induce apoptosis, which is initiated by the mitochondrial pathway (Vermeulen et al., Experimen Hemat 2002;30:1107). In this study, the mechanism of CDK inhibitor-induced apoptosis was further characterized. The expression of two Bcl-2 family members (Bcl-2 and Bax) was examined in malignant hematopoietic cell lines after treatment with CDK inhibitors. Bcl-2 prolongs cell survival by inhibiting The activity of cyclin-dependent kinases (CDK), the key regulators of the cell cycle, is strictly controlled by different mechanisms but is often altered in human cancer. This has stimulated the search for molecules targeting CDK activity as anti-canceragents. Different types of CDK inhibitors have been described, among them, C2-, N6-, N9-substituted purines such as plant cytokinin analogues. We have previously reported the inhibition of CDK1 and CDK2 activity by a new group of plant cytokinin analogu es (Vermeulen et al., Leukemia 2001;16:299). These compounds inhibit proliferation of leukemic cell lines and induce apoptosis, which is initiated by the mitochondrial pathway (Vermeulen et al., Experimen Hemat 2002;30:1107). In this study, the mechanism of CDK inhibitor-induced apoptosis was further characterized. The expression of two Bcl-2 family members (Bcl-2 and Bax) was examined in malignant hematopoietic cell lines after treatment with CDK inhibitors. Bcl-2 prolongs cell survival by inhibiting (en)
Title	The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest (en)
skos:prefLabel	The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest The antiproliferative effect of a plant cytokinin analogue with inhibitory activity on cyclin-dependent kinases (CDK) is associated with cell cycle delay rather than with cell cycle arrest (en)
skos:notation	RIV/61989592:15310/03:00001601!RIV/2004/GA0/153104/N
http://linked.open.../vavai/riv/strany	207
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA301/02/0475)
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Strnad, Miroslav
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	598642
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/03:00001601
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cytokinin, inhibitor CDK (en)
http://linked.open.../riv/klicoveSlovo	cytokinin inhibitor CDK
http://linked.open...ontrolniKodProRIV	[FEEA89E1856A]
http://linked.open...v/mistoKonaniAkce	Paris, France
http://linked.open...i/riv/mistoVydani	New York
http://linked.open...i/riv/nazevZdroje	Experimental Hematology
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Purine inhibitors of cyclin-dependent kinases as anticancer and antimitotic compounds
http://linked.open...UplatneniVysledku	2003
http://linked.open...iv/tvurceVysledku	Strnad, Miroslav Van Onckelen, H. Lenjou, M. Vermeulen, K. Berneman, Z. Mijs, G. Van Bockstaele, D. Venken, T.
http://linked.open...vavai/riv/typAkce	WRD - Světová
issn	0301-472X
number of pages	246 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Elsevier
http://localhost/t...ganizacniJednotka	15310

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