About: Estimation of partition coefficients by MEKC - Part I: Potential pharmaceuticals based on 2-guinolone and 2-indolone

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Estimation of partition coefficients by MEKC - Part I: Potential pharmaceuticals based on 2-guinolone and 2-indolone Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The octanol-water partition coefficients of 18 potential pharmaceuticals derived from 2-quinolone and 2-indolone were measured by means of MEKC. Their values range from 2.2 to 4.7 (expressed in logarithmic form). The critical micelle concentration (CIVIC) of SIDS was determined conductometrically and the partial specific volumes of the micelles in the buffer (25 mM sodium borate, pH 9.5) were calculated from density data. The values were used for determination of the phase ratio and for estimation of the micelle-water (K-mw) and octanol water (K-ow) partition coefficients. Direct calculation of K-ow from the easily measurable capacity factors (le) gives results comparable with those laboriously determined from K-mw. Extrapolation of the micellar time from the set of migration times of alkylbenzene standards proved to be viable alternative to measurements using a marker. The octanol-water partition coefficients of 18 potential pharmaceuticals derived from 2-quinolone and 2-indolone were measured by means of MEKC. Their values range from 2.2 to 4.7 (expressed in logarithmic form). The critical micelle concentration (CIVIC) of SIDS was determined conductometrically and the partial specific volumes of the micelles in the buffer (25 mM sodium borate, pH 9.5) were calculated from density data. The values were used for determination of the phase ratio and for estimation of the micelle-water (K-mw) and octanol water (K-ow) partition coefficients. Direct calculation of K-ow from the easily measurable capacity factors (le) gives results comparable with those laboriously determined from K-mw. Extrapolation of the micellar time from the set of migration times of alkylbenzene standards proved to be viable alternative to measurements using a marker. (en)
Title	Estimation of partition coefficients by MEKC - Part I: Potential pharmaceuticals based on 2-guinolone and 2-indolone Estimation of partition coefficients by MEKC - Part I: Potential pharmaceuticals based on 2-guinolone and 2-indolone (en)
skos:prefLabel	Estimation of partition coefficients by MEKC - Part I: Potential pharmaceuticals based on 2-guinolone and 2-indolone Estimation of partition coefficients by MEKC - Part I: Potential pharmaceuticals based on 2-guinolone and 2-indolone (en)
skos:notation	RIV/61989592:15310/01:00001303!RIV/2002/MSM/153102/N
http://linked.open.../vavai/riv/strany	723-728
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 151100003), Z(MSM 153100013)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Adamovský, Pavel Barták, Petr Ulrichová, Jitka Bednář, Petr Ševčík, Juraj
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	679618
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/01:00001303
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MICELLAR ELECTROKINETIC CHROMATOGRAPHY; PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR-STRUCTURE; CAPILLARY CHROMATOGRAPHY; CAPACITY FACTORS; N-OCTANOL; INDEX (en)
http://linked.open.../riv/klicoveSlovo	INDEX CAPACITY FACTORS CAPILLARY CHROMATOGRAPHY N-OCTANOL PERFORMANCE LIQUID CHROMATOGRAPHY MICELLAR ELECTROKINETIC CHROMATOGRAPHY MOLECULAR-STRUCTURE
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[5CE631D097C8]
http://linked.open...i/riv/nazevZdroje	Journal of Separation Science
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	24
http://linked.open...iv/tvurceVysledku	Barták, Petr Bednář, Petr Ulrichová, Jitka Ševčík, Juraj Adamovský, Pavel Gavenda, A. Tzoumas, P.
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20151100003 http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20153100013
issn	1615-9314
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	15310

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 77 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software