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| Description
| - Background: Elevated gamma-glutamyl transpeptidase (GGT) is present approximately in half of all patients with non-alcoholic fatty liver disease (NAFLD). NAFLD is the liver manifestation of metabolic syndrome (MS). This study aimed to explore the relationship between GGT and MS or proinflammatory parameters. Methods: Data from the cross-sectional HepaMeta study conducted in Slovakia in 2011 among Roma living in rural communities were used. Participants (n = 446) were divided into 2 groups; those with elevated GGT and those with normal GGT levels. MS was diagnosed according to the International Diabetes Federation criteria; presence of central obesity and low density lipoproteins (LDL) or high density lipoproteins (HDL), high triglycerides, hypertension, glucose intolerance or type 2 diabetes. Participants were tested for the presence of MS and its components, and biochemical tests for lipid levels (total cholesterol, HDL, LDL, TG) and inflammatory parameters (high sensitivity C-reactive protein - hs-CRP and ferritin) were performed. Results: Of 446 Roma participants, only 29 (6.5%) had GGT levels above the normal value. After exclusion of patients with viral hepatitis and alcohol abuse, patients with elevated GGT suffered from MS more often (p { 0.001), and patients with more MS components had a higher risk of elevated GGT. We found a significant association between GGT and the individual MS components, except HDL (waist circumference?94cm in men or 80 cm in women: p { 0.01; BMI } 30: p { 0.001; fasting glucose?5.6 mmol/l: p { 0.001; arterial hypertension: p { 0.05, and TAG?1.7 mmol/l: p { 0.001). Patients with elevated GGT levels had also significantly higher hs-CRP (hs-CRP} 2 mg/l: p { 0.001; hs-CRP} 3 mg/l: p { 0.001) and ferritin (ferritin } 300 mg/l: p { 0.01) levels. Conclusion: Patients with MS have more significantly elevated levels of GGT. There is a significant association of GGT with individual MS components, except HDL and inflammatory parameters.
- Background: Elevated gamma-glutamyl transpeptidase (GGT) is present approximately in half of all patients with non-alcoholic fatty liver disease (NAFLD). NAFLD is the liver manifestation of metabolic syndrome (MS). This study aimed to explore the relationship between GGT and MS or proinflammatory parameters. Methods: Data from the cross-sectional HepaMeta study conducted in Slovakia in 2011 among Roma living in rural communities were used. Participants (n = 446) were divided into 2 groups; those with elevated GGT and those with normal GGT levels. MS was diagnosed according to the International Diabetes Federation criteria; presence of central obesity and low density lipoproteins (LDL) or high density lipoproteins (HDL), high triglycerides, hypertension, glucose intolerance or type 2 diabetes. Participants were tested for the presence of MS and its components, and biochemical tests for lipid levels (total cholesterol, HDL, LDL, TG) and inflammatory parameters (high sensitivity C-reactive protein - hs-CRP and ferritin) were performed. Results: Of 446 Roma participants, only 29 (6.5%) had GGT levels above the normal value. After exclusion of patients with viral hepatitis and alcohol abuse, patients with elevated GGT suffered from MS more often (p { 0.001), and patients with more MS components had a higher risk of elevated GGT. We found a significant association between GGT and the individual MS components, except HDL (waist circumference?94cm in men or 80 cm in women: p { 0.01; BMI } 30: p { 0.001; fasting glucose?5.6 mmol/l: p { 0.001; arterial hypertension: p { 0.05, and TAG?1.7 mmol/l: p { 0.001). Patients with elevated GGT levels had also significantly higher hs-CRP (hs-CRP} 2 mg/l: p { 0.001; hs-CRP} 3 mg/l: p { 0.001) and ferritin (ferritin } 300 mg/l: p { 0.01) levels. Conclusion: Patients with MS have more significantly elevated levels of GGT. There is a significant association of GGT with individual MS components, except HDL and inflammatory parameters. (en)
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| Title
| - Gamma-glutamyl transpeptidase level associated with metabolic syndrome and proinflammatory parameters in the young Roma population in Eastern Slovakia: a population-based study
- Gamma-glutamyl transpeptidase level associated with metabolic syndrome and proinflammatory parameters in the young Roma population in Eastern Slovakia: a population-based study (en)
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| skos:prefLabel
| - Gamma-glutamyl transpeptidase level associated with metabolic syndrome and proinflammatory parameters in the young Roma population in Eastern Slovakia: a population-based study
- Gamma-glutamyl transpeptidase level associated with metabolic syndrome and proinflammatory parameters in the young Roma population in Eastern Slovakia: a population-based study (en)
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| skos:notation
| - RIV/61989592:15260/14:33151508!RIV15-MSM-15260___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15260/14:33151508
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - ferritin; hs-CRP; non-alcoholic fatty liver disease; metabolic syndrome; gamma-glutamyl transpeptidase (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Central European Journal of Public Health
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Madarasová Gecková, Andrea
- Kristian, Pavol
- Jarčuška, Pavol
- Jarčuška, Peter
- Pella, Daniel
- Mareková, Mária
- Dražilová, Sylvia
- Fedačko, Ján
- Janičko, Martin
- Siegfried, Leonard
- Veselíny, Eduard
- Senajová, Gabriela
- Tkáč Jr., Michal
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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