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| Description
| - Accelerated atherosclerosis in sytemic lupus erythematosus (SLE) is an important cause of morbidity and mortality. The pathophysiology of accelerated atherosclerosis in SLE is mediated by factors such as inflammatory processes in the vascular wall, specific antibodies, dylipoproteinemia, endothelial dysfunction and the high prevalence of traditional risk factors for cardiovascular disease. In this kontext, we evluated the clinical signifikance of ultrasound examination of the Hrotic arteries in the early diagnosis of atherosclerosis. The study included 63 patients with SLE (female: male 53:10, 38.4?12.7 years, mean disease durativ 143,0?82,6 months), 24 patients had lupus nephritis. The control group consisted of 24 volunteers (female: male 20:4 mean age 31,04?8.59). Intima media thickness (IMT) was measured by ultrasound on both sides. The results were correlated with markers of lipid spektrum, anti-dsDNA, antinucleosomal and anticardiolipin antibodies, lupus antikoagulant and komplement components. Clinical disease activity and damage were evaluated by SLEDAI and SLICC indices. Lifestyle and other important factors were examined per protokol and by questionnaire. A signifiant diference of IMT (P?0,03) was found between the lupus patients and sex-age a adjusted healthy control with an in mean IMT in SLE patients of 0,569?0,11 mm, in control group 0,495?0,05 mm. A signifiant correlation between IMT and disease durativ, age, positivity of lupus antikoagulant, use of ACE inhibitors, glomerular filtration and serum kreatinine were found. No diference in IMT was found between patients with or without lupus nephritis. IMT measurement could be used as a clinical predátor of risk of accelerated atherosclerosis in lupus patients.
- Accelerated atherosclerosis in sytemic lupus erythematosus (SLE) is an important cause of morbidity and mortality. The pathophysiology of accelerated atherosclerosis in SLE is mediated by factors such as inflammatory processes in the vascular wall, specific antibodies, dylipoproteinemia, endothelial dysfunction and the high prevalence of traditional risk factors for cardiovascular disease. In this kontext, we evluated the clinical signifikance of ultrasound examination of the Hrotic arteries in the early diagnosis of atherosclerosis. The study included 63 patients with SLE (female: male 53:10, 38.4?12.7 years, mean disease durativ 143,0?82,6 months), 24 patients had lupus nephritis. The control group consisted of 24 volunteers (female: male 20:4 mean age 31,04?8.59). Intima media thickness (IMT) was measured by ultrasound on both sides. The results were correlated with markers of lipid spektrum, anti-dsDNA, antinucleosomal and anticardiolipin antibodies, lupus antikoagulant and komplement components. Clinical disease activity and damage were evaluated by SLEDAI and SLICC indices. Lifestyle and other important factors were examined per protokol and by questionnaire. A signifiant diference of IMT (P?0,03) was found between the lupus patients and sex-age a adjusted healthy control with an in mean IMT in SLE patients of 0,569?0,11 mm, in control group 0,495?0,05 mm. A signifiant correlation between IMT and disease durativ, age, positivity of lupus antikoagulant, use of ACE inhibitors, glomerular filtration and serum kreatinine were found. No diference in IMT was found between patients with or without lupus nephritis. IMT measurement could be used as a clinical predátor of risk of accelerated atherosclerosis in lupus patients. (en)
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| Title
| - Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient
- Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient (en)
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| skos:prefLabel
| - Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient
- Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient (en)
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| skos:notation
| - RIV/61989592:15110/14:33152002!RIV15-MSM-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/14:33152002
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - intima media thickness; atherosclerosis; systemic lupus erythematodes (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Biomedical Papers-Olomouc
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Heřmanová, Zuzana
- Horák, Pavel
- Langová, Kateřina
- Skácelová, Martina
- Smržová, Andrea
- Zadražil, Josef
- Novotný, Dalibor
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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