About: RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling

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About: RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.bloodjournal.org/content/123/3/391?sso-checked=true
Description	Overexpression of transcription factors RUNX1 and NF-E2 was reported in granulocytes of patients with polycythemia vera and other myeloproliferative neoplasms (MPN). We report that RUNX1 and NF-E2 overexpression is not specific for MPN because it was not detected in patients with EPO receptor (EPOR) mutations, suggesting distinct mechanisms by which erythroid progenitors in polycythemias with defects of hypoxia sensing and EPOR mutations exert their EPO-hypersensitivity. Overexpression of transcription factors RUNX1 and NF-E2 was reported in granulocytes of patients with polycythemia vera and other myeloproliferative neoplasms (MPN). We report that RUNX1 and NF-E2 overexpression is not specific for MPN because it was not detected in patients with EPO receptor (EPOR) mutations, suggesting distinct mechanisms by which erythroid progenitors in polycythemias with defects of hypoxia sensing and EPOR mutations exert their EPO-hypersensitivity. (en)
Title	RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling (en)
skos:prefLabel	RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling (en)
skos:notation	RIV/61989592:15110/14:33151198!RIV15-MSM-15110___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(EE2.3.20.0164), P(EE2.3.30.0041), P(GAP305/11/1745), S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	DIVOKÝ, Vladimír Horváthová, Monika Kapraľová, Katarína Piterková, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	43578
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/14:33151198
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	transcription factors; NF-E2; RUNX1; polycythemia (en)
http://linked.open.../riv/klicoveSlovo	NF-E2 RUNX1 transcription factors polycythemia
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B6E91F67B8F1]
http://linked.open...i/riv/nazevZdroje	Blood (print)
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Podpora vytváření excelentních výzkumných týmů a intersektorální mobility na Univerzitě Palackého v Olomouci II. Genetic analysis of EPOR signal transduction in iron depleted erythropoiesis International research network
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	123
http://linked.open...iv/tvurceVysledku	Divoký, Vladimír Horváthová, Monika Kapraľová, Katarína Prchal, Josef T. Lorenzo, Felipe Láníková, Lucie Song, Jihyun
http://linked.open...ain/vavai/riv/wos	000329748700018
issn	0006-4971
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1182/blood-2013-10-534222
http://localhost/t...ganizacniJednotka	15110

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