About: Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice     Goto   Sponge   NotDistinct   Permalink

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  • Lovastatin showed anti-proliferative effects in vitro and led to significantly smaller tumor sizes in vivo compared to vehicle-treatment. 13cRA promoted tumor cell growth in vitro and led to significantly larger viable tumor mass and significantly faster increase of viable tumor mass in vivo over time compared to vehicle- and lovastatin-treatment. However, when combined with lovastatin, 13cRA enhanced the anti-proliferative effect of lovastatin in vivo. The combination-treated mice showed slowest tumor growth of all groups with significantly slower tumor growth compared to the vehicle-treated mice and significantly smaller tumor sizes. Moreover, the combination-treated group displayed the smallest size of viable tumor mass and the slowest increase in viable tumor mass over time of all groups, with a significant difference compared to the vehicle- and 13cRA-treated group. The combination-treated tumors showed highest extent of necrosis, lowest median microvessel density (MVD) and highest expression of alpha-smooth muscle actin. The combination of highe MVD and low alpha-SMA is a predictor of poor prognosis in other tumor entities.
  • Lovastatin showed anti-proliferative effects in vitro and led to significantly smaller tumor sizes in vivo compared to vehicle-treatment. 13cRA promoted tumor cell growth in vitro and led to significantly larger viable tumor mass and significantly faster increase of viable tumor mass in vivo over time compared to vehicle- and lovastatin-treatment. However, when combined with lovastatin, 13cRA enhanced the anti-proliferative effect of lovastatin in vivo. The combination-treated mice showed slowest tumor growth of all groups with significantly slower tumor growth compared to the vehicle-treated mice and significantly smaller tumor sizes. Moreover, the combination-treated group displayed the smallest size of viable tumor mass and the slowest increase in viable tumor mass over time of all groups, with a significant difference compared to the vehicle- and 13cRA-treated group. The combination-treated tumors showed highest extent of necrosis, lowest median microvessel density (MVD) and highest expression of alpha-smooth muscle actin. The combination of highe MVD and low alpha-SMA is a predictor of poor prognosis in other tumor entities. (en)
Title
  • Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice
  • Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice (en)
skos:prefLabel
  • Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice
  • Combination of 13-cis retinoid acid and lovastatin: marked anti-tumor potential in vivo in a pheochromocytoma allograft model in female athymic nude mice (en)
skos:notation
  • RIV/61989592:15110/14:33150458!RIV15-MSM-15110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 7
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http://linked.open...aciTvurceVysledku
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http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 7801
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/14:33150458
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • pheochromocytoma; 13-cis retinoic acid; lovastatin (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [8852D5FF086A]
http://linked.open...i/riv/nazevZdroje
  • Endocrinology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 155
http://linked.open...iv/tvurceVysledku
  • Schovánek, Jan
  • Giubellino, Alessio
  • Nolting, Svenja
  • Tayem, Yasin
issn
  • 0013-7227
number of pages
http://bibframe.org/vocab/doi
  • 10.1210/en.2014-1027
http://localhost/t...ganizacniJednotka
  • 15110
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