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Description
| - Tumor suppressor genes (TSGs) are commonly inactivated by somatic mutation and/or promoter methylation; yet., recent high-throughput genomic studies have not identified key TSGs inactivated by both mechanisms. We pursued an integrated molecular analysis based on methylation binding domain sequencing (MBD-seq), 450K Methylation arrays, whole exome sequencing, and whole genome gene expression arrays in primary head and neck squamous cell carcinoma (HNSCC) tumors and matched uvulopalatopharyngoplasty tissue samples (UPPPs).
- Tumor suppressor genes (TSGs) are commonly inactivated by somatic mutation and/or promoter methylation; yet., recent high-throughput genomic studies have not identified key TSGs inactivated by both mechanisms. We pursued an integrated molecular analysis based on methylation binding domain sequencing (MBD-seq), 450K Methylation arrays, whole exome sequencing, and whole genome gene expression arrays in primary head and neck squamous cell carcinoma (HNSCC) tumors and matched uvulopalatopharyngoplasty tissue samples (UPPPs). (en)
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Title
| - Key tumor suppressor genes inactivated by %22greater promoter%22 methylation and somatic mutations in head and neck cancer
- Key tumor suppressor genes inactivated by %22greater promoter%22 methylation and somatic mutations in head and neck cancer (en)
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skos:prefLabel
| - Key tumor suppressor genes inactivated by %22greater promoter%22 methylation and somatic mutations in head and neck cancer
- Key tumor suppressor genes inactivated by %22greater promoter%22 methylation and somatic mutations in head and neck cancer (en)
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skos:notation
| - RIV/61989592:15110/14:33149294!RIV15-MSM-15110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/14:33149294
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - somatic mutations, integration analysis; DNA methylation; Tumor Suppressor Genes; Head and Neck Squamous Cell Carcinoma (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Žižková, Veronika
- Agrawal, Nishant
- Califano, Joseph
- Fertig, Elana
- Frederick, Mitchell
- Guerrero-Preston, Rafael
- Hadar, Tal
- Koch, Wayne
- Marchionni, Luigi
- Michailidi, Christina
- Myers, Jeffrey
- Noordhuis, Maartje
- Pickering, Curtis
- Sidransky, David
- Velculescu, Victor
- Westra, William
- Yegnasubramanian, Srinivasan
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
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http://localhost/t...ganizacniJednotka
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