About: Silymarin and its constituents in cardiac preconditioning

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://ac.els-cdn.com/S0367326X14001464/1-s2.0-S0367326X14001464-main.pdf?_tid=185b4eca-029a-11e4-ad1d-00000aab0f01&acdnat=1404382338_018bf55bd16dd8cfe201527de84e2889
Description	Silymarin, a standardised extract of Silybum marianum (milk thistle), comprises mainly of silybin, with dehydrosilybin (DHSB), quercetin, taxifolin, silychristin and a number of other compounds which are known to possess a range of salutary effects. Indeed, there is evidence for their role in reducing tumour growth, preventing liver toxicity, and protecting a number of organs against ischemic damage. The hepatoprotective effects of silymarin, especially in preventing Amanita and alcohol intoxication induced damage to the liver, are a well established fact. Likewise, there is weighty evidence that silymarin possesses antimicrobial and anticancer activities. Additionally, it has emerged that in animal models, silymarin can protect the heart, brain, liver and kidneys against ischemia reperfusion injury, probably by preconditioning. The mechanisms of preconditioning are, in general, well studied, especially in the heart. On the other hand, the mechanism by which silymarin protects the heart from ischemia remains largely unexplored. This review, therefore, focuses on evaluating existing studies on silymarin induced cardioprotection in the context of the established mechanisms of preconditioning. Silymarin, a standardised extract of Silybum marianum (milk thistle), comprises mainly of silybin, with dehydrosilybin (DHSB), quercetin, taxifolin, silychristin and a number of other compounds which are known to possess a range of salutary effects. Indeed, there is evidence for their role in reducing tumour growth, preventing liver toxicity, and protecting a number of organs against ischemic damage. The hepatoprotective effects of silymarin, especially in preventing Amanita and alcohol intoxication induced damage to the liver, are a well established fact. Likewise, there is weighty evidence that silymarin possesses antimicrobial and anticancer activities. Additionally, it has emerged that in animal models, silymarin can protect the heart, brain, liver and kidneys against ischemia reperfusion injury, probably by preconditioning. The mechanisms of preconditioning are, in general, well studied, especially in the heart. On the other hand, the mechanism by which silymarin protects the heart from ischemia remains largely unexplored. This review, therefore, focuses on evaluating existing studies on silymarin induced cardioprotection in the context of the established mechanisms of preconditioning. (en)
Title	Silymarin and its constituents in cardiac preconditioning Silymarin and its constituents in cardiac preconditioning (en)
skos:prefLabel	Silymarin and its constituents in cardiac preconditioning Silymarin and its constituents in cardiac preconditioning (en)
skos:notation	RIV/61989592:15110/14:33149240!RIV15-MSM-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(EE2.3.30.0041), P(GAP301/11/0662)
http://linked.open...iv/cisloPeriodika	C
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Modrianský, Martin Zholobenko, Aleksey
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	44869
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/14:33149240
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Signalling pathways; Quercetin; Silybin; Silymarin; Preconditioning; Ischemia (en)
http://linked.open.../riv/klicoveSlovo	Ischemia Silybin Preconditioning Signalling pathways Quercetin Silymarin
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[67F84EF189B3]
http://linked.open...i/riv/nazevZdroje	Fitoterapia
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Podpora vytváření excelentních výzkumných týmů a intersektorální mobility na Univerzitě Palackého v Olomouci II. Elucidation of the mechanism of flavonoid-dependent cardioprotection and changes in the bioenergetic status of the cell
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	97
http://linked.open...iv/tvurceVysledku	Modrianský, Martin Zholobenko, Aleksey
issn	0367-326X
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.fitote.2014.05.016
http://localhost/t...ganizacniJednotka	15110

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