About: Derivatives of 2-phenyl-3-hydroxyquinoline-4(1H)-one and methods of their preparation and utilization

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Description	Derivatives of 2-phenyl-3-hydroxyquinoline-4(1H)-one of the general formula (II) where X represents a nitro group, amino group, and Y represents an atom of halogen, oxygen or sulphur substituted by C1 to C6 alkyl or phenyl group, whereby both the alkyl and phenyl group may be further substituted and the substituents may be identical or different, or by nitrogen substituted independently by hydrogen, C1 to C6 alkyl, C1 to C6 alkyl, which may be substituted among others by halogen, hydroxy, C1 to C4 alkoxy or C1 to C4 alkylamino group, or may form a saturated or unsaturated heterocyclic ring with 5 to 7 atoms, where the individual ring atoms comprise atoms of carbon, and any of the carbon atoms may be substituted by an atom of nitrogen, sulphur or oxygen, X and Y together form an imidazo group, or imidazo group substituted by C1 to C6 alkyl, which may be substituted among others by halogen, hydroxy, C1 to C4 alkoxy or C1 to C4 alkylamino group, CHO or acetylgroup, or a heterocyclic ring with 5 to 6 atoms, where the ring atoms may be further substituted. Methods of preparation of these compounds are described. In addition, their cytostatic, cytotoxic, antiproliferation and immunosuppressive activity is described including examples of their potential pharmacological and pharmaceutical utilization. Derivatives of 2-phenyl-3-hydroxyquinoline-4(1H)-one of the general formula (II) where X represents a nitro group, amino group, and Y represents an atom of halogen, oxygen or sulphur substituted by C1 to C6 alkyl or phenyl group, whereby both the alkyl and phenyl group may be further substituted and the substituents may be identical or different, or by nitrogen substituted independently by hydrogen, C1 to C6 alkyl, C1 to C6 alkyl, which may be substituted among others by halogen, hydroxy, C1 to C4 alkoxy or C1 to C4 alkylamino group, or may form a saturated or unsaturated heterocyclic ring with 5 to 7 atoms, where the individual ring atoms comprise atoms of carbon, and any of the carbon atoms may be substituted by an atom of nitrogen, sulphur or oxygen, X and Y together form an imidazo group, or imidazo group substituted by C1 to C6 alkyl, which may be substituted among others by halogen, hydroxy, C1 to C4 alkoxy or C1 to C4 alkylamino group, CHO or acetylgroup, or a heterocyclic ring with 5 to 6 atoms, where the ring atoms may be further substituted. Methods of preparation of these compounds are described. In addition, their cytostatic, cytotoxic, antiproliferation and immunosuppressive activity is described including examples of their potential pharmacological and pharmaceutical utilization. (en)
Title	Derivatives of 2-phenyl-3-hydroxyquinoline-4(1H)-one and methods of their preparation and utilization Derivatives of 2-phenyl-3-hydroxyquinoline-4(1H)-one and methods of their preparation and utilization (en)
skos:prefLabel	Derivatives of 2-phenyl-3-hydroxyquinoline-4(1H)-one and methods of their preparation and utilization Derivatives of 2-phenyl-3-hydroxyquinoline-4(1H)-one and methods of their preparation and utilization (en)
skos:notation	RIV/61989592:15110/13:33147813!RIV14-MSM-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(EE2.3.20.0009)
http://linked.open...cisloPatentuVzoru	EP 2064200
http://linked.open...eleniPatentuVzoru	2013-09-04 (xsd:date)
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Hajdúch, Marián
http://linked.open.../riv/druhVysledku	P - Patent
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	68471
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/13:33147813
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	quinolinone, anticancer activity, synthesis, activity (en)
http://linked.open.../riv/klicoveSlovo	anticancer activity quinolinone synthesis activity
http://linked.open...ontrolniKodProRIV	[2AAA305B3EA8]
http://linked.open.../licencniPoplatek	A - Poskytovatel licence na výsledek požaduje licenční poplatek
http://linked.open...ydaniPatentuVzoru	Munich, The Hague, Berlin, Vienna, Brussels
http://linked.open...atelePatentuVzoru	Evropský patentový úřad
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Combinatorial chemistry in research and education
http://linked.open...UplatneniVysledku	2013
http://linked.open...iv/tvurceVysledku	Hajdúch, Marián Hlaváč, Jan Hradil, Pavel Krejčí, Petr
http://linked.open...mniOchranaPatentu	A - EPO (Evropský patentový úřad)
http://linked.open...avai/riv/vlastnik	Univerzita Palackého
http://linked.open...itiJinymSubjektem	A - Nabytí licence je nutné vždy
http://linked.open...uzitiPatentuVzoru	A - Pouze udělený nebo využívaný pouze vlastníkem
http://linked.open...stnikPatentuVzoru	Univerzita Palackého
http://localhost/t...ganizacniJednotka	15110

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