About: Concomitant JAK2 V617F?positive polycythemia vera and B?cell chronic lymphocytic leukemia in three patients originating from two separate hematopoietic stem cells

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About: Concomitant JAK2 V617F?positive polycythemia vera and B?cell chronic lymphocytic leukemia in three patients originating from two separate hematopoietic stem cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://onlinelibrary.wiley.com/doi/10.1002/ajh.23362/pdf
Description	The simultaneous occurrence of polycythemia vera (PV) and chronic lymphocytic leukemia (CLL) is a rare event that offers a possibility to study their common origin. PV originates from self-renewing hematopoietic stem cells (HSC) with both lymphoid and myeloid potential. It has been reported that CLL also originates from self-renewing HSC with a potential for both lymphoid and myeloid differentiation. We report three females with concomitant CLL and PV whose X-chromosome inactivation patterns of the neoplastic cells revealed that granulocytes/platelets and Blymphocytes used different X-chromosome alleles. These data indicate that both PV and CLL have arisen independently and from different HSC. The simultaneous occurrence of polycythemia vera (PV) and chronic lymphocytic leukemia (CLL) is a rare event that offers a possibility to study their common origin. PV originates from self-renewing hematopoietic stem cells (HSC) with both lymphoid and myeloid potential. It has been reported that CLL also originates from self-renewing HSC with a potential for both lymphoid and myeloid differentiation. We report three females with concomitant CLL and PV whose X-chromosome inactivation patterns of the neoplastic cells revealed that granulocytes/platelets and Blymphocytes used different X-chromosome alleles. These data indicate that both PV and CLL have arisen independently and from different HSC. (en)
Title	Concomitant JAK2 V617F?positive polycythemia vera and B?cell chronic lymphocytic leukemia in three patients originating from two separate hematopoietic stem cells Concomitant JAK2 V617F?positive polycythemia vera and B?cell chronic lymphocytic leukemia in three patients originating from two separate hematopoietic stem cells (en)
skos:prefLabel	Concomitant JAK2 V617F?positive polycythemia vera and B?cell chronic lymphocytic leukemia in three patients originating from two separate hematopoietic stem cells Concomitant JAK2 V617F?positive polycythemia vera and B?cell chronic lymphocytic leukemia in three patients originating from two separate hematopoietic stem cells (en)
skos:notation	RIV/61989592:15110/13:33145939!RIV14-MZ0-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NT13576), P(NT13587)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	INDRÁK, Karel DIVOKÝ, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	66673
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/13:33145939
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hematopoetic stem cells; B-CLL; V617F; polycythemia vera (en)
http://linked.open.../riv/klicoveSlovo	V617F hematopoetic stem cells B-CLL polycythemia vera
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[8799BDA1611C]
http://linked.open...i/riv/nazevZdroje	American Journal of Hematology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	11 (xsd:int)
http://linked.open...vavai/riv/projekt	Integrated genomic analysis of chronic lymphocytic leukemia (CLL) for genetic and clinical identification of subgroups with aberrations of selected chromosomes. Molecular pathophysiology of selected congenital disorders of erythropoiesis
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	88
http://linked.open...iv/tvurceVysledku	Indrák, Karel Jarošová, Marie Kučerová, Jana Jelínek, Jaroslav Divoký, Vladimír Prchal, Josef T. Liu, Enli Naušová, Jitka Roda, Paul Swierczek, Sabina Urbánková, Helena
http://linked.open...ain/vavai/riv/wos	000314149700016
issn	0361-8609
number of pages	2 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/ajh.23362
http://localhost/t...ganizacniJednotka	15110

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