About: The causes and consequences of genetic heterogeneity in cancer evolution

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability. This instability leads to an increased mutation rate and can shape the evolution of the cancer genome through a plethora of mechanisms. By understanding these mechanisms we can gain insight into the common pathways of tumour evolution that could support the development of future therapeutic strategies. Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability. This instability leads to an increased mutation rate and can shape the evolution of the cancer genome through a plethora of mechanisms. By understanding these mechanisms we can gain insight into the common pathways of tumour evolution that could support the development of future therapeutic strategies. (en)
Title	The causes and consequences of genetic heterogeneity in cancer evolution The causes and consequences of genetic heterogeneity in cancer evolution (en)
skos:prefLabel	The causes and consequences of genetic heterogeneity in cancer evolution The causes and consequences of genetic heterogeneity in cancer evolution (en)
skos:notation	RIV/61989592:15110/13:33145701!RIV14-MSM-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED0030/01/01)
http://linked.open...iv/cisloPeriodika	7467
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Bártek, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	64434
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/13:33145701
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CLONAL EVOLUTION; REPLICATION STRESS; MUTATIONAL PROCESSES; MICROSATELLITE INSTABILITY; CELL LUNG-CANCER; 21 BREAST CANCERS; DNA-DAMAGE RESPONSE; INTRA-TUMOR HETEROGENEITY; CHROMOSOME SEGREGATION ERRORS; ACUTE MYELOID-LEUKEMIA (en)
http://linked.open.../riv/klicoveSlovo	REPLICATION STRESS CELL LUNG-CANCER 21 BREAST CANCERS ACUTE MYELOID-LEUKEMIA CHROMOSOME SEGREGATION ERRORS CLONAL EVOLUTION INTRA-TUMOR HETEROGENEITY MICROSATELLITE INSTABILITY MUTATIONAL PROCESSES DNA-DAMAGE RESPONSE
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C4CCD2071FAB]
http://linked.open...i/riv/nazevZdroje	Nature
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedicine for regional development and human resources
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	501
http://linked.open...iv/tvurceVysledku	Bártek, Jiří Burrell, Ra Mcgranahan, N. Swanton, C.
http://linked.open...ain/vavai/riv/wos	000324545700032
issn	0028-0836
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1038/nature12625
http://localhost/t...ganizacniJednotka	15110

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