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| rdf:type
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| Description
| - The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water- insoluble terpenoid having a free carboxylic functional group is derivatized on this functional group with a substituent selected from the group comprising quarternary ammonium substituents of general formula Xb bound to the carboxy group of the terpenoid, wherein Xb is - (CH2)n N+R3-, quarternary ammonium substituents of general formula Xc bound to the carboxy group of the terpenoid, wherein Xc je -(CH2)nR+Y-, glycosylic substituents Xe bound by a or J3 glycosidic bond to the carboxy group of the terpenoid, wherein Xe is selected from the group comprising glucosyl, galactosyl, arabinosyl, rhamnosyl, lacyosyl, cellobiosyl, maltosyl and the 2-deoxyanalogues thereof, and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid,containing an inclusion complex of the derivatized pentacyclic or tetra-cyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation.
- The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water- insoluble terpenoid having a free carboxylic functional group is derivatized on this functional group with a substituent selected from the group comprising quarternary ammonium substituents of general formula Xb bound to the carboxy group of the terpenoid, wherein Xb is - (CH2)n N+R3-, quarternary ammonium substituents of general formula Xc bound to the carboxy group of the terpenoid, wherein Xc je -(CH2)nR+Y-, glycosylic substituents Xe bound by a or J3 glycosidic bond to the carboxy group of the terpenoid, wherein Xe is selected from the group comprising glucosyl, galactosyl, arabinosyl, rhamnosyl, lacyosyl, cellobiosyl, maltosyl and the 2-deoxyanalogues thereof, and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid,containing an inclusion complex of the derivatized pentacyclic or tetra-cyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation. (en)
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| Title
| - METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION
- METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION (en)
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| skos:prefLabel
| - METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION
- METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION (en)
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| skos:notation
| - RIV/61989592:15110/13:33145210!RIV14-TA0-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(ED0030/01/01), P(TE01020028)
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| http://linked.open...cisloPatentuVzoru
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| http://linked.open...eleniPatentuVzoru
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/13:33145210
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - terpenoid; tetracyclic; pentacyclic (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open.../licencniPoplatek
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| http://linked.open...ydaniPatentuVzoru
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| http://linked.open...atelePatentuVzoru
| - Canadian Intellectual Property Office (CIPO)
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...ydaniPatentuVzoru
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| http://linked.open...iv/tvurceVysledku
| - Hajdúch, Marián
- Nováková, Kateřina
- Svoboda, Michal
- Šarek, Jan
- Biedermann, David
- Spáčilová, Pavla
- Kubelka, Tomas
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| http://linked.open...mniOchranaPatentu
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| http://linked.open...avai/riv/vlastnik
| |
| http://linked.open...itiJinymSubjektem
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| http://linked.open...uzitiPatentuVzoru
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| http://linked.open...stnikPatentuVzoru
| - Univerzita Karlova v Praze, Přírodovědecká fakulta; Univerzita Palackého v Olomouci; I.Q.A. a.s.
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| http://localhost/t...ganizacniJednotka
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