About: Enhanced Chromatin Dynamics by FACT Promotes Transcriptional Restart after UV-Induced DNA Damage

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Chromatin remodeling is tightly linked to all DNA-transacting activities. To study chromatin remodeling during DNA repair, we established quantitative fluorescence imaging methods to measure the exchange of histones in chromatin in living cells. We show that particularly H2A and H2B are evicted and replaced at an accelerated pace at sites of UV-induced DNA damage. This accelerated exchange of H2A/H2B is facilitated by SPT16, one of the two subunits of the histone chaperone FACT (facilitates chromatin transcription) but largely independent of its partner SSRP1. Interestingly, SPT16 is targeted to sites of UV light-induced DNA damage-arrested transcription and is required for efficient restart of RNA synthesis upon damage removal. Together, our data uncover an important role for chromatin dynamics at the crossroads of transcription and the UV-induced DNA damage response. Chromatin remodeling is tightly linked to all DNA-transacting activities. To study chromatin remodeling during DNA repair, we established quantitative fluorescence imaging methods to measure the exchange of histones in chromatin in living cells. We show that particularly H2A and H2B are evicted and replaced at an accelerated pace at sites of UV-induced DNA damage. This accelerated exchange of H2A/H2B is facilitated by SPT16, one of the two subunits of the histone chaperone FACT (facilitates chromatin transcription) but largely independent of its partner SSRP1. Interestingly, SPT16 is targeted to sites of UV light-induced DNA damage-arrested transcription and is required for efficient restart of RNA synthesis upon damage removal. Together, our data uncover an important role for chromatin dynamics at the crossroads of transcription and the UV-induced DNA damage response. (en)
Title	Enhanced Chromatin Dynamics by FACT Promotes Transcriptional Restart after UV-Induced DNA Damage Enhanced Chromatin Dynamics by FACT Promotes Transcriptional Restart after UV-Induced DNA Damage (en)
skos:prefLabel	Enhanced Chromatin Dynamics by FACT Promotes Transcriptional Restart after UV-Induced DNA Damage Enhanced Chromatin Dynamics by FACT Promotes Transcriptional Restart after UV-Induced DNA Damage (en)
skos:notation	RIV/61989592:15110/13:33145000!RIV14-MSM-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED0030/01/01)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Bártek, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	72922
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/13:33145000
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	REPLICATION; SPT16; DOMAIN; HUMAN-CELLS; NUCLEOSOME DYNAMICS; IN-VIVO; PROTEIN-KINASE CK2; HISTONE CHAPERONE FACT; NUCLEOTIDE EXCISION-REPAIR; RNA-POLYMERASE-II (en)
http://linked.open.../riv/klicoveSlovo	NUCLEOTIDE EXCISION-REPAIR HUMAN-CELLS HISTONE CHAPERONE FACT NUCLEOSOME DYNAMICS PROTEIN-KINASE CK2 RNA-POLYMERASE-II SPT16 DOMAIN IN-VIVO REPLICATION
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2349B23CBFE7]
http://linked.open...i/riv/nazevZdroje	Molecular Cell
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	14 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedicine for regional development and human resources
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	51
http://linked.open...iv/tvurceVysledku	Bártek, Jiří Dinant, Ch. Ampatziadis-Michailidis, G. Fousteri, M. Grosbart, M. Houtsmuller, Ab Kimura, H. Lagarou, A. Lans, H. Marteijn, Ja. Theil, Af Tresini, M. Van Cappellen, Wa Vermeulen, W.
http://linked.open...ain/vavai/riv/wos	000323693900007
issn	1097-2765
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.molcel.2013.08.007
http://localhost/t...ganizacniJednotka	15110

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