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  • Gastrointestinal stroma tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and are oftern associated with KIT or PDGFRA gene mutations. GIST cells might arise from the interstitial cells of Cajal (ICCs) or from a mesenchymal precursor that is common to ICCs and smooth muscle cells (SMCs). Here, we analyzed the mRNA and protein expression of RNA-Binding Protein with Multiple Splicing-2 (RBPMS2), an early marker of gastrointestinal SMC precursors, in human GISTs (n=23) by in situ hybridization, quantitative RT-PCR analysis and immunohistochemistry.
  • Gastrointestinal stroma tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and are oftern associated with KIT or PDGFRA gene mutations. GIST cells might arise from the interstitial cells of Cajal (ICCs) or from a mesenchymal precursor that is common to ICCs and smooth muscle cells (SMCs). Here, we analyzed the mRNA and protein expression of RNA-Binding Protein with Multiple Splicing-2 (RBPMS2), an early marker of gastrointestinal SMC precursors, in human GISTs (n=23) by in situ hybridization, quantitative RT-PCR analysis and immunohistochemistry. (en)
Title
  • High expression of the RNA-binding protein RBPMS1 in gastrointestinal stromal tumors
  • High expression of the RNA-binding protein RBPMS1 in gastrointestinal stromal tumors (en)
skos:prefLabel
  • High expression of the RNA-binding protein RBPMS1 in gastrointestinal stromal tumors
  • High expression of the RNA-binding protein RBPMS1 in gastrointestinal stromal tumors (en)
skos:notation
  • RIV/61989592:15110/13:33144974!RIV14-MSM-15110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 2
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  • 77336
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/13:33144974
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • interstitial cell of Cajal; smooth muscle cells; KIT; RBPMS2; RNA-binding protein; Gastrointestinal stromal tumors (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [3F44C908C782]
http://linked.open...i/riv/nazevZdroje
  • Experimental and Molecular Pathology
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 94
http://linked.open...iv/tvurceVysledku
  • Veselý, Jaroslav
  • Škarda, Jozef
  • Janíková, Mária
  • Rypka, Miroslav
  • Bernex, Florence
  • De Santa Barbara, Pascal
  • Faure, Sandrine
  • Hapkova, Ilona
  • Notarnicola, Cécile
  • Rouleau, Caroline
  • Thys, An
  • Vanderwinden, Jean-Marie
issn
  • 0014-4800
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.yexmp.2012.12.004
http://localhost/t...ganizacniJednotka
  • 15110
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