About: Systemic effect of asthma bronchiale on expression of multidrug resistance protein 1 in peripheral blood lymphocytes amongst children

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About: Systemic effect of asthma bronchiale on expression of multidrug resistance protein 1 in peripheral blood lymphocytes amongst children Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It is influenced by the activity of the immune system and transports certain immunomodulatory drugs (e.g. glucocorticoids) from the intracellular to the extracellular space. Increased expression of the MDR1 protein in lymphocytes may therefore lead to undesirable reduction of lymphocytic concentration of these drugs. The aim of the study was to assess the systemic effect of asthma on the expression of the MDR1 protein in lymphocytes. The expression of MDR1 in peripheral blood lymphocytes (PBLs) was determined by a flow cytometry analysis with indirect immunofluorescence staining technique amongst 20 children (aged from 1.85 to 16.38 years) with newly diagnosed, mild persistent asthma (prior therapy) and amongst 30 healthy children (aged from 0.15 to 17.08 years). There was a significantly lower PBLs MDR1 expression (median MDR1 expression, p { 0.02) and a significantly lower proportion of the population of MDR1-positive PBLs as well (percentage of MDR1-postitive PBLs, p { 5.39.10-3) It is influenced by the activity of the immune system and transports certain immunomodulatory drugs (e.g. glucocorticoids) from the intracellular to the extracellular space. Increased expression of the MDR1 protein in lymphocytes may therefore lead to undesirable reduction of lymphocytic concentration of these drugs. The aim of the study was to assess the systemic effect of asthma on the expression of the MDR1 protein in lymphocytes. The expression of MDR1 in peripheral blood lymphocytes (PBLs) was determined by a flow cytometry analysis with indirect immunofluorescence staining technique amongst 20 children (aged from 1.85 to 16.38 years) with newly diagnosed, mild persistent asthma (prior therapy) and amongst 30 healthy children (aged from 0.15 to 17.08 years). There was a significantly lower PBLs MDR1 expression (median MDR1 expression, p { 0.02) and a significantly lower proportion of the population of MDR1-positive PBLs as well (percentage of MDR1-postitive PBLs, p { 5.39.10-3) (en)
Title	Systemic effect of asthma bronchiale on expression of multidrug resistance protein 1 in peripheral blood lymphocytes amongst children Systemic effect of asthma bronchiale on expression of multidrug resistance protein 1 in peripheral blood lymphocytes amongst children (en)
skos:prefLabel	Systemic effect of asthma bronchiale on expression of multidrug resistance protein 1 in peripheral blood lymphocytes amongst children Systemic effect of asthma bronchiale on expression of multidrug resistance protein 1 in peripheral blood lymphocytes amongst children (en)
skos:notation	RIV/61989592:15110/13:33144966!RIV14-MSM-15110___
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Potěšil, Jan Kopřiva, František Džubák, Petr Hajdúch, Marián
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	109694
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/13:33144966
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Peripheral blood lymphocyte; P-glycoprotein; Multidrug resistance protein 1; MDR1; Asthma (en)
http://linked.open.../riv/klicoveSlovo	Asthma MDR1 Multidrug resistance protein 1 Peripheral blood lymphocyte P-glycoprotein
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[9286C511CC0D]
http://linked.open...i/riv/nazevZdroje	Alergie
http://linked.open...in/vavai/riv/obor	FC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Džubák, Petr Hajdúch, Marián Kopřiva, František Potěšil, Jan Donevská, S.
issn	1212-3536
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	15110

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