About: Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection

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About: Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	OBJECTIVE AND DESIGN: Prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty (TJA). We conducted a genetic association study that investigated whether selected coding variants of the genes for Toll-like receptors (TLR)2 and TLR4 may contribute to genetic susceptibility for PJI. SUBJECTS AND METHODS: In total, 350 patients with TJA (98 with PJI/252 without PJI), and 189 unrelated healthy Czech individuals without TJA were enrolled in our study. Three missense polymorphisms of the genes encoding for TLR2 (TLR2 R753Q, rs5743708) and TLR4 (TLR4 D299G, rs4986790 and T399I, rs4986791) were genotyped by %22TaqMan%22 assay. RESULTS: The frequencies of less common variants for the investigated TLR2/TLR4 polymorphisms in healthy individuals were similar to those observed in other Caucasian populations. Importantly, the distribution of TLR2/TLR4 genotype alleles did not differ between the patients with PJI and the control groups of patients with nonseptic prostheses/healthy individuals. CONCLUSION: Our data suggest that structural genetic variants of the receptors TLR2 and TLR4 do not substantially affect the risk of prosthetic joint infection. OBJECTIVE AND DESIGN: Prosthetic joint infection (PJI) is a severe complication of total joint arthroplasty (TJA). We conducted a genetic association study that investigated whether selected coding variants of the genes for Toll-like receptors (TLR)2 and TLR4 may contribute to genetic susceptibility for PJI. SUBJECTS AND METHODS: In total, 350 patients with TJA (98 with PJI/252 without PJI), and 189 unrelated healthy Czech individuals without TJA were enrolled in our study. Three missense polymorphisms of the genes encoding for TLR2 (TLR2 R753Q, rs5743708) and TLR4 (TLR4 D299G, rs4986790 and T399I, rs4986791) were genotyped by %22TaqMan%22 assay. RESULTS: The frequencies of less common variants for the investigated TLR2/TLR4 polymorphisms in healthy individuals were similar to those observed in other Caucasian populations. Importantly, the distribution of TLR2/TLR4 genotype alleles did not differ between the patients with PJI and the control groups of patients with nonseptic prostheses/healthy individuals. CONCLUSION: Our data suggest that structural genetic variants of the receptors TLR2 and TLR4 do not substantially affect the risk of prosthetic joint infection. (en)
Title	Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection (en)
skos:prefLabel	Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection Coding variants of TLR2 and TLR4 genes do not substantially contribute to prosthetic joint infection (en)
skos:notation	RIV/61989592:15110/13:33143925!RIV14-MZ0-15110___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED0030/01/01), P(NS10260)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Sťahelová, Anna Petřek, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	65867
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/13:33143925
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Total joint arthroplasty; Susceptibility; Genetic risk; Gene polymorphism; Total joint prosthesis (en)
http://linked.open.../riv/klicoveSlovo	Genetic risk Total joint arthroplasty Total joint prosthesis Gene polymorphism Susceptibility
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[16DD911A886F]
http://linked.open...i/riv/nazevZdroje	Inflammation Research
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedicine for regional development and human resources Individual susceptibility to periprosthetic joint infection: a role of variants in genes coding for innate immunity receptors and for chemotactic / proinflammatory cytokines
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	62
http://linked.open...iv/tvurceVysledku	Gallo, Jiří Mrázek, František Petřek, Martin Sťahelová, Anna
http://linked.open...ain/vavai/riv/wos	000317647400005
issn	1023-3830
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1007/s00011-013-0601-8
http://localhost/t...ganizacniJednotka	15110

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