About: Methylation of AR locus does not always reflect X chromosome inactivation state

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://bloodjournal.hematologylibrary.org/content/119/13/e100.full.pdf+html
Description	Determination of clonality on the basis of assays of inactivation of genes encoded on the X chromosome has provided important insights into the origins of neoplastic diseases, helped to decipher the hierarchy of hematopoiesis, and provided a mechanism for differentiating between inherited and acquired disorders, for distinguishing between clonal and reactive acquired hematologic abnormalities and for showing cell selection in female carriers of X-linked inherited processes. The methylation status of CpG sites close to the trinucleotide repeats in exon 1 of the human androgen receptor (AR) X chromosome gene assay (HUMARA) has been used to determine clonality. This HUMARA at times indicated clonal hematopoiesis in healthy elderly women, thus precluding its applicability. We used a clonality assay based on quantitative expression of polymorphic X chromosome genes (qTCA) and found no evidence of clonal hematopoiesis in healthy nonanemic elderly persons. These data provide the molecular basis of incomplete correlation with the pattern of DNA methylation of this X chromosome AR gene locus. Determination of clonality on the basis of assays of inactivation of genes encoded on the X chromosome has provided important insights into the origins of neoplastic diseases, helped to decipher the hierarchy of hematopoiesis, and provided a mechanism for differentiating between inherited and acquired disorders, for distinguishing between clonal and reactive acquired hematologic abnormalities and for showing cell selection in female carriers of X-linked inherited processes. The methylation status of CpG sites close to the trinucleotide repeats in exon 1 of the human androgen receptor (AR) X chromosome gene assay (HUMARA) has been used to determine clonality. This HUMARA at times indicated clonal hematopoiesis in healthy elderly women, thus precluding its applicability. We used a clonality assay based on quantitative expression of polymorphic X chromosome genes (qTCA) and found no evidence of clonal hematopoiesis in healthy nonanemic elderly persons. These data provide the molecular basis of incomplete correlation with the pattern of DNA methylation of this X chromosome AR gene locus. (en)
Title	Methylation of AR locus does not always reflect X chromosome inactivation state Methylation of AR locus does not always reflect X chromosome inactivation state (en)
skos:prefLabel	Methylation of AR locus does not always reflect X chromosome inactivation state Methylation of AR locus does not always reflect X chromosome inactivation state (en)
skos:notation	RIV/61989592:15110/12:33141042!RIV13-MSM-15110___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	13
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Piterková, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	149802
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/12:33141042
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	X-chromosome inactivation; TCA; HUMARA (en)
http://linked.open.../riv/klicoveSlovo	TCA HUMARA X-chromosome inactivation
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[63709E02CA31]
http://linked.open...i/riv/nazevZdroje	Blood
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	119
http://linked.open...iv/tvurceVysledku	Jelínek, Jaroslav Agarwal, Neeraj Cairns, Bradley Hammoud, Sue Hickman, Kimberly Parker, Charles J Piterková, Lucie Prchal, Josef T. Swierczek, Sabina I Wilson, Andrew
http://linked.open...ain/vavai/riv/wos	000302141200001
issn	0006-4971
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1182/blood-2011-11-390351
http://localhost/t...ganizacniJednotka	15110

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