About: Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450: NewWay to OvercomeMultidrug Resistance?     Goto   Sponge   NotDistinct   Permalink

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  • Embryonic and tumour cells are able to protect themselves against various harmful compounds. In human pathology, this phenomenon exists in the form of multidrug resistance (MDR) that significantly deteriorates success of anticancer treatment. Cytochromes P450 (CYPs) play one of the key roles in the xenobiotic metabolism. CYP expression could contribute to resistance of cancer cells to chemotherapy. CYP epoxygenases (CYP2C and CYP2J) metabolize about 20% of clinically important drugs. Besides of drug metabolism, CYP epoxygenases and their metabolites play important role in embryos, normal body function, and tumors. They participate in angiogenesis, mitogenesis, and cell signaling. It was found that CYP epoxygenases are affected by peroxisome proliferator-activated receptor alfa (PPARalfa). Based on the results of current studies, we assume that PPARs ligands may regulate CYP2C and CYP2J and in some extent they may contribute to overcoming of MDR in patients with different types of tumours.
  • Embryonic and tumour cells are able to protect themselves against various harmful compounds. In human pathology, this phenomenon exists in the form of multidrug resistance (MDR) that significantly deteriorates success of anticancer treatment. Cytochromes P450 (CYPs) play one of the key roles in the xenobiotic metabolism. CYP expression could contribute to resistance of cancer cells to chemotherapy. CYP epoxygenases (CYP2C and CYP2J) metabolize about 20% of clinically important drugs. Besides of drug metabolism, CYP epoxygenases and their metabolites play important role in embryos, normal body function, and tumors. They participate in angiogenesis, mitogenesis, and cell signaling. It was found that CYP epoxygenases are affected by peroxisome proliferator-activated receptor alfa (PPARalfa). Based on the results of current studies, we assume that PPARs ligands may regulate CYP2C and CYP2J and in some extent they may contribute to overcoming of MDR in patients with different types of tumours. (en)
Title
  • Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450: NewWay to OvercomeMultidrug Resistance?
  • Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450: NewWay to OvercomeMultidrug Resistance? (en)
skos:prefLabel
  • Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450: NewWay to OvercomeMultidrug Resistance?
  • Peroxisome Proliferator-Activated Receptors in Regulation of Cytochromes P450: NewWay to OvercomeMultidrug Resistance? (en)
skos:notation
  • RIV/61989592:15110/12:33140514!RIV13-MSM-15110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 158282
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15110/12:33140514
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • tumour; embryo; CYP2J; CYP2C; cytochrome P450; peroxisome proliferator-activated receptor; multidrug resistance (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [3E5FB159DBCB]
http://linked.open...i/riv/nazevZdroje
  • Journal of Biomedicine and Biotechnology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 2012
http://linked.open...iv/tvurceVysledku
  • Ehrmann, Jiří
  • Erdösová, Běla
  • Konieczna, Anna
  • Lichnovská, Radka
  • Čížková, Kateřina
http://linked.open...ain/vavai/riv/wos
  • 000310622600001
issn
  • 1110-7243
number of pages
http://bibframe.org/vocab/doi
  • 10.1155/2012/656428
http://localhost/t...ganizacniJednotka
  • 15110
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