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| Description
| - The review deals with the probable etiology, diagnostics, classification, most likely causative drugs, risk factors and disease course of drug-induced cholestasis. Cholestatic and mixed forms of drug-induced liver injury (DILI) account for nearly half of all reported cases. Medications are probably responsible for 2 - 5 % of cases of jaundice requiring hospital admission; moreover, all forms of DILI are currently the most common adverse drug reaction resulting in withdrawal of new drugs from clinical research. Cholestatic syndromes caused by drugs can be divided into acute (bland cholestasis, cholestatic hepatitis and cholangiolitis) and, less frequent, chronic (vanishing bile duct syndrome and extrahepatic biliary obstruction). The etiology seems to be mostly idiosyncratic, with a supposed genetic predisposition. Bile salt export pump (BSEP) is known to be subject to drug inhibition in susceptible patients. Besides rare mutations that have been linked to drug-induced cholestasis, the common p.V444A polymorphism of BSEP, DRB1*1501 HLA class II haplotype and homozygosity for GSTM1 null and/or GSTT1 null alleles have been identified as a potential risk factors. No specific tests are available for establishing drug etiology of cholestasis; therefore causality assessment is performed in the same way as in other adverse drug reactions. Several structured causality assessment methods for DILI have also been proposed, e.g. RUCAM, CIOMS score etc. Drugs known to cause cholestatic syndromes include various antibiotics, oral contraceptives, oral antidiabetics and numerous other drugs including herbal medicines.
- The review deals with the probable etiology, diagnostics, classification, most likely causative drugs, risk factors and disease course of drug-induced cholestasis. Cholestatic and mixed forms of drug-induced liver injury (DILI) account for nearly half of all reported cases. Medications are probably responsible for 2 - 5 % of cases of jaundice requiring hospital admission; moreover, all forms of DILI are currently the most common adverse drug reaction resulting in withdrawal of new drugs from clinical research. Cholestatic syndromes caused by drugs can be divided into acute (bland cholestasis, cholestatic hepatitis and cholangiolitis) and, less frequent, chronic (vanishing bile duct syndrome and extrahepatic biliary obstruction). The etiology seems to be mostly idiosyncratic, with a supposed genetic predisposition. Bile salt export pump (BSEP) is known to be subject to drug inhibition in susceptible patients. Besides rare mutations that have been linked to drug-induced cholestasis, the common p.V444A polymorphism of BSEP, DRB1*1501 HLA class II haplotype and homozygosity for GSTM1 null and/or GSTT1 null alleles have been identified as a potential risk factors. No specific tests are available for establishing drug etiology of cholestasis; therefore causality assessment is performed in the same way as in other adverse drug reactions. Several structured causality assessment methods for DILI have also been proposed, e.g. RUCAM, CIOMS score etc. Drugs known to cause cholestatic syndromes include various antibiotics, oral contraceptives, oral antidiabetics and numerous other drugs including herbal medicines. (en)
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| Title
| - Drug-induced cholestatic liver injury
- Drug-induced cholestatic liver injury (en)
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| skos:prefLabel
| - Drug-induced cholestatic liver injury
- Drug-induced cholestatic liver injury (en)
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| skos:notation
| - RIV/61989592:15110/12:33139127!RIV13-GA0-15110___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/12:33139127
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - adversedrug reaction; cholestatic hepatitis; drug-induced liver injury; Cholestatis (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/mistoVydani
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| http://linked.open...vEdiceCisloSvazku
| - Cell Biology Research Progress
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| http://linked.open...i/riv/nazevZdroje
| - Bilirubin Chemistry, Regulation and Disorder
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...v/pocetStranKnihy
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Krystyník, Ondřej
- Procházka, Vlastimil
- Urbánek, Karel
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| number of pages
| |
| http://purl.org/ne...btex#hasPublisher
| - Nova Science Publishers, Inc.
|
| https://schema.org/isbn
| |
| http://localhost/t...ganizacniJednotka
| |
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