About: Acute myeloid leukemia with minimal differentiation: Unusual cytogenetics, morphology, phenotype and clinical course

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About: Acute myeloid leukemia with minimal differentiation: Unusual cytogenetics, morphology, phenotype and clinical course Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	1. Introduction The diagnosis of acute myeloid leukemia (AML) requires the identification of more than 20% of the blasts in the bone marrow or the peripheral blood, with the expression of myeloid markers, such as CD13 and CD33, and positivity for myeloperoxidase (MPO) and/or anti-MPO. AML with an unusual phenotype is seen in less than 10% of all cases [1], and AML with minimal differentiation (AML-NOS; not otherwise specified, WHO 2008) is a rare subtype of acute leukemia in which the blasts normally do not show morphological differentiation and the conventional cytochemical staining is negative. The prognosis of patients with this AML subtype is remarkably poor [2] and [3]. 1. Introduction The diagnosis of acute myeloid leukemia (AML) requires the identification of more than 20% of the blasts in the bone marrow or the peripheral blood, with the expression of myeloid markers, such as CD13 and CD33, and positivity for myeloperoxidase (MPO) and/or anti-MPO. AML with an unusual phenotype is seen in less than 10% of all cases [1], and AML with minimal differentiation (AML-NOS; not otherwise specified, WHO 2008) is a rare subtype of acute leukemia in which the blasts normally do not show morphological differentiation and the conventional cytochemical staining is negative. The prognosis of patients with this AML subtype is remarkably poor [2] and [3]. (en)
Title	Acute myeloid leukemia with minimal differentiation: Unusual cytogenetics, morphology, phenotype and clinical course Acute myeloid leukemia with minimal differentiation: Unusual cytogenetics, morphology, phenotype and clinical course (en)
skos:prefLabel	Acute myeloid leukemia with minimal differentiation: Unusual cytogenetics, morphology, phenotype and clinical course Acute myeloid leukemia with minimal differentiation: Unusual cytogenetics, morphology, phenotype and clinical course (en)
skos:notation	RIV/61989592:15110/12:33138773!RIV13-MSM-15110___
http://linked.open...avai/riv/aktivita	S Z
http://linked.open...avai/riv/aktivity	S, Z(MSM6198959205)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	PAPAJÍK, Tomáš FLODR, Patrik INDRÁK, Karel Rohoň, Peter Jarošová, Marie Prekopová, Ivana Hubáček, Jaromír Pikalová, Zuzana Holzerová, Milena Nedomová, Radka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Lékařská fakulta
http://linked.open...dnocenehoVysledku	120998
http://linked.open...ai/riv/idVysledku	RIV/61989592:15110/12:33138773
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	MLL amplification; Tetraploidization; Clonal evolution; Segmental jumping translocation; Homogeneously staining region; Complex karyotype; Acute myeloid leukemia with minimal differentiation (en)
http://linked.open.../riv/klicoveSlovo	Acute myeloid leukemia with minimal differentiation Clonal evolution Complex karyotype Homogeneously staining region MLL amplification Segmental jumping translocation Tetraploidization
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2CE759C45040]
http://linked.open...i/riv/nazevZdroje	Leukemia Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	10 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	36
http://linked.open...iv/tvurceVysledku	Hubáček, Jaromír Indrák, Karel Jarošová, Marie Pikalová, Zuzana Rohoň, Peter Papajík, Tomáš Flodr, Patrik Holzerová, Milena Nedomová, Radka Prekopová, Ivana
http://linked.open...n/vavai/riv/zamer	Studies of genes and molecular mechanisms involved in regulation of hematopoiesis, their clinical impact and targeted treatment
issn	0145-2126
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.leukres.2012.03.004
http://localhost/t...ganizacniJednotka	15110

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